{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:32:56Z","timestamp":1791822776026,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Statin\u2010associated muscle symptoms (SAMS) are a major determinant of poor treatment adherence and\/or discontinuation, but a definitive diagnosis of SAMS is challenging. The PROSISA study was an observational retrospective study aimed to assess the prevalence of reported SAMS in a cohort of dyslipidaemic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic\/anamnestic data, biochemical values and occurrence of SAMS were collected by 23 Italian Lipid Clinics. Adjusted logistic regression was performed to estimate odds ratio (OR) and 95% confidence intervals for association between probability of reporting SAMS and several factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analyses were carried out on 16\u00a0717 statin\u2010treated patients (mean\u00a0\u00b1\u00a0SD, age 60.5\u00a0\u00b1\u00a012.0\u00a0years; 52.1% men). During statin therapy, 9.6% (<jats:italic>N<\/jats:italic>\u00a0=\u00a01599) of patients reported SAMS. Women and physically active subjects were more likely to report SAMS (OR 1.23 [1.10\u20131.37] and OR 1.35 [1.14\u20131.60], respectively), whist age\u00a0\u2265\u00a065 (OR 0.79 [0.70\u20130.89]), presence of type 2 diabetes mellitus (OR 0.62 [0.51\u20130.74]), use of concomitant nonstatin lipid\u2010lowering drugs (OR 0.87 [0.76\u20130.99]), use of high\u2010intensity statins (OR 0.79 [0.69\u20130.90]) and use of potential interacting drugs (OR 0.63 [0.48\u20130.84]) were associated with lower probability of reporting SAMS. Amongst patients reporting SAMS, 82.2% underwent dechallenge (treatment interruption) and\/or rechallenge (change or restart of statin therapy), with reappearance of muscular symptoms in 38.4% (3.01% of the whole cohort).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The reported prevalence of SAMS was 9.6% of the whole PROSISA cohort, but only a third of patients still reported SAMS after dechallenge\/rechallenge. These results emphasize the need for a better management of SAMS to implement a more accurate diagnosis and treatment re\u2010evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13219","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T23:42:45Z","timestamp":1606866165000},"page":"116-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real\u2010life setting: the PROSISA Study"],"prefix":"10.1111","volume":"290","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-5361","authenticated-orcid":false,"given":"M.","family":"Casula","sequence":"first","affiliation":[{"name":"Epidemiology and Preventive Pharmacology Service (SEFAP) Department of Pharmacological and Biomolecular Sciences University of Milan Milan Italy"},{"name":"IRCCS MultiMedica Milan 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