{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:39:36Z","timestamp":1762868376007,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>SARS\u2010CoV\u20102, the COVID\u201019 causative agent, has infected millions of people and killed over 1.6 million worldwide. A small percentage of cases persist with prolonged positive RT\u2010PCR on nasopharyngeal swabs. The aim of this study was to determine risk factors for prolonged viral shedding amongst patient\u2019s basal clinical conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have evaluated all 513 patients attended in our hospital between 1 March and 1 July. We have selected all 18 patients with prolonged viral shedding and compared them with 36 sex\u2010matched randomly selected controls. Demographic, treatment and clinical data were systematically collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Global median duration of viral clearance was 25.5\u00a0days (<jats:italic>n<\/jats:italic>\u00a0=\u00a054; IQR, 22\u201339.3\u00a0days), 48.5\u00a0days in cases (IQR 38.7\u201354.9\u00a0days) and 23\u00a0days in controls (IQR 20.2\u201325.7), respectively. There were not observed differences in demographic, symptoms or treatment data between groups.<\/jats:p><jats:p>Chronic rhinosinusitis and atopy were more common in patients with prolonged viral shedding (67%) compared with controls (11% and 25% respectively) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). The use of inhaled corticosteroids was also more frequent in case group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007). Multivariate analysis indicated that CRS (odds ratio [OR], 18.78; 95% confidence interval [95%CI], 3.89\u201390.59; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) was independently associated with prolonged SARS\u2010CoV\u20102 RNA shedding in URT samples, after adjusting for initial PCR Ct values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found that chronic rhinosinusitis and atopy might be associated with increased risk of prolonged viral shedding. If confirmed in prospective trials, this finding might have clinical implications for quarantine duration due to increased risk of pandemic spread.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13237","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T08:57:45Z","timestamp":1609232265000},"page":"921-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Chronic rhinosinusitis is associated with prolonged SARS\u2010CoV\u20102 RNA shedding in upper respiratory tract samples: A case\u2010control study"],"prefix":"10.1111","volume":"289","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2111-1020","authenticated-orcid":false,"given":"B.","family":"Recalde\u2010Zamacona","sequence":"first","affiliation":[{"name":"From the Covid19 Department Clinica Pamplona Spain"},{"name":"Pulmonary Medicine Department Clinica Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9216-4461","authenticated-orcid":false,"given":"A.","family":"Tom\u00e1s\u2010Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"From the Covid19 Department Clinica Pamplona Spain"},{"name":"Dermatology Department Clinica Universidad de Navarra Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Campo","sequence":"additional","affiliation":[{"name":"From the Covid19 Department Clinica Pamplona Spain"},{"name":"Pulmonary Medicine Department Clinica Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Satr\u00fastegui\u2010Alzugaray","sequence":"additional","affiliation":[{"name":"Primary Care Health Center of San Juan Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fern\u00e1ndez\u2010Alonso","sequence":"additional","affiliation":[{"name":"From the Covid19 Department Clinica Pamplona Spain"},{"name":"Microbiology and Infectious Diseases Division Clinica Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"I\u00f1igo","sequence":"additional","affiliation":[{"name":"From the Covid19 Department Clinica Pamplona Spain"},{"name":"Microbiology and Infectious Diseases Division Clinica Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rodr\u00edguez\u2010Mateos","sequence":"additional","affiliation":[{"name":"From the Covid19 Department Clinica Pamplona Spain"},{"name":"Microbiology and Infectious Diseases Division Clinica Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Di Frisco","sequence":"additional","affiliation":[{"name":"From the Covid19 Department Clinica Pamplona Spain"},{"name":"Pulmonary Medicine Department Clinica Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Felgueroso","sequence":"additional","affiliation":[{"name":"From the Covid19 Department Clinica Pamplona Spain"},{"name":"Pulmonary Medicine Department Clinica Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bert\u00f3","sequence":"additional","affiliation":[{"name":"From the Covid19 Department Clinica Pamplona Spain"},{"name":"Pulmonary Medicine Department Clinica Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mar\u00edn\u2010Oto","sequence":"additional","affiliation":[{"name":"From the Covid19 Department Clinica Pamplona Spain"},{"name":"Pulmonary Medicine Department Clinica Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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