{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:40:00Z","timestamp":1773369600938,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 2017\/513"],"award-info":[{"award-number":["CAN 2017\/513"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The outcome for diffuse large B\u2010cell lymphoma (DLBCL) patients has improved with the immunochemotherapy combination R\u2010CHOP. An increased rate of heart failure is well documented following this treatment, whereas incidence and outcome of other cardiac complications, for example myocardial infarction, are less well known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We identified 3548 curatively treated DLBCL patients in Sweden diagnosed between 2007 and 2014, and 35474 matched lymphoma\u2010free general population comparators. The incidence, characteristics and outcome of acute myocardial infarctions (AMIs) were assessed using population\u2010based registers up to 11\u00a0years after diagnosis. The rate of AMI was estimated using flexible parametric models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, a 33% excess rate of AMI was observed among DLBCL patients compared with the general population (HR: 1.33, 95% CI: 1.14\u20131.55). The excess rate was highest during the first year after diagnosis and diminished after 2\u00a0years. High age, male sex and comorbidity were the strongest risk factors for AMI. Older patients (&gt;70\u00a0years) with mild comorbidities (i.e. hypertension or diabetes) had a 61% higher AMI rate than comparators (HR: 1.61, 95% CI: 1.10\u20132.35), whereas the corresponding excess rate was 28% for patients with severe comorbidities (HR: 1.28, 95% CI: 1.01\u20131.64). Among younger patients (\u226470), a short\u2010term excess rate of AMI was limited to those with severe comorbidities. There was no difference in AMI characteristics, pharmacological treatment or 30\u2010day survival among patients and comparators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DLBCL patients have an increased risk of AMI, especially during the first 2\u00a0years, which calls for improved cardiac monitoring guided by age and comorbidities. Importantly, DLBCL was not associated with differential AMI management or survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13303","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T13:31:33Z","timestamp":1621344693000},"page":"1048-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Myocardial infarction in diffuse large B\u2010cell lymphoma patients \u2013 a population\u2010based matched cohort study"],"prefix":"10.1111","volume":"290","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-467X","authenticated-orcid":false,"given":"S.","family":"Ekberg","sequence":"first","affiliation":[{"name":"From the Division of Clinical Epidemiology Department of Medicine Solna Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4955-4728","authenticated-orcid":false,"given":"S.","family":"Harrysson","sequence":"additional","affiliation":[{"name":"From the Division of Clinical Epidemiology Department of Medicine Solna Karolinska Institutet Stockholm Sweden"},{"name":"Department of Hematology Karolinska University Hospital Solna Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1695-379X","authenticated-orcid":false,"given":"T.","family":"Jernberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Danderyd University Hospital Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0994-8135","authenticated-orcid":false,"given":"K.","family":"Szummer","sequence":"additional","affiliation":[{"name":"Section of Cardiology Department of Medicine Karolinska Institutet Stockholm Sweden"},{"name":"Department of Cardiology Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.\u2010O.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Hematology South \u00c4lvsborg Hospital Bor\u00e5s Sweden"},{"name":"Sahlgrenska Academy Gothenburg University Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-6707","authenticated-orcid":false,"given":"M.","family":"Jerkeman","sequence":"additional","affiliation":[{"name":"Division of Oncology Lund University and Skane University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2104-3320","authenticated-orcid":false,"given":"K. 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