{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:07:39Z","timestamp":1792519659321,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["W\u20101253 DK HOROS"],"award-info":[{"award-number":["W\u20101253 DK HOROS"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Comorbidities including ischemic heart disease (IHD) worsen outcomes after SARS\u2010CoV\u20102 infections. High lipoprotein(a) [Lp(a)] concentrations are a strong risk factor for IHD and possibly for thromboembolic events. We therefore evaluated whether SARS\u2010CoV\u20102 infections modify the risk of high Lp(a) concentrations for IHD or thromboembolic events during the first 8.5 months follow\u2010up of the pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Cohort study using data from the UK Biobank during the SARS\u2010CoV\u20102 pandemic. Baseline Lp(a) was compared between SARS\u2010CoV\u20102 positive patients and the population controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SARS\u2010CoV\u20102 positive patients had Lp(a) concentrations similar to the population controls. The risk for IHD increased with higher Lp(a) concentrations in both, the population controls (\n                      <jats:italic>n<\/jats:italic>\n                      = 435,104) and SARS\u2010CoV\u20102 positive patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 6937). The causality of the findings was supported by a genetic risk score for Lp(a). A SARS\u2010CoV\u20102 infection modified the association with a steeper increase in risk for infected patients (interaction\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value = 0.03). Although SARS\u2010CoV\u20102 positive patients had a five\u2010times higher frequency of thromboembolic events compared to the population controls (1.53% vs. 0.31%), the risk was not influenced by Lp(a).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SARS\u2010CoV\u20102 infections enforce the association between high Lp(a) and IHD but the risk for thromboembolic events is not influenced by Lp(a).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.13338","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T09:21:53Z","timestamp":1623057713000},"page":"101-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Lipoprotein(a) and SARS\u2010CoV\u20102 infections: Susceptibility to infections, ischemic heart disease and thromboembolic events"],"prefix":"10.1111","volume":"291","author":[{"given":"Silvia","family":"Di Maio","sequence":"first","affiliation":[{"name":"Department of Genetics and Pharmacology Institute of Genetic Epidemiology, Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lamina","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pharmacology Institute of Genetic Epidemiology, Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Coassin","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pharmacology Institute of Genetic Epidemiology, Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Forer","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pharmacology Institute of Genetic Epidemiology, Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"W\u00fcrzner","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Microbiology and Public Health Institute of Hygiene &amp; Medical Microbiology Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Sch\u00f6nherr","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pharmacology Institute of Genetic Epidemiology, Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2229-1120","authenticated-orcid":false,"given":"Florian","family":"Kronenberg","sequence":"additional","affiliation":[{"name":"Department of Genetics and Pharmacology Institute of Genetic Epidemiology, Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1985"},{"key":"e_1_2_8_3_1","article-title":"Thrombosis and COVID\u201019: controversies and (tentative) conclusions","author":"Connors JM","year":"2021","journal-title":"Clin Infect Dis"},{"key":"e_1_2_8_4_1","article-title":"Venous thromboembolism and major bleeding in patients with COVID\u201019: a nationwide population\u2010based cohort study","author":"Dalager\u2010Pedersen M","year":"2021","journal-title":"Clin Infect Dis"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2012.02592.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R060582"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvaa247"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30088-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa171"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2015432"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-020-00867-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13070"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000397"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003553"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/ATVBAHA.120.315291","article-title":"Lp(a) (lipoprotein[a]) concentrations and incident atherosclerotic cardiovascular disease: new insights from a large national biobank","volume":"41","author":"Patel AP","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.120.003182"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M076232"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.070"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003083"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R071233"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa420"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joim.13338","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T06:21:19Z","timestamp":1725171679000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.13338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,29]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/joim.13338"],"URL":"https:\/\/doi.org\/10.1111\/joim.13338","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,29]]},"assertion":[{"value":"2021-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}