{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:13:51Z","timestamp":1791818031369,"version":"4.3.4"},"reference-count":171,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK128289"],"award-info":[{"award-number":["DK128289"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 058404"],"award-info":[{"award-number":["P30 058404"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK56621"],"award-info":[{"award-number":["R01 DK56621"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P50CA236733"],"award-info":[{"award-number":["P50CA236733"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease is comprised of either simple steatosis (non\u2010alcoholic fatty liver) or a more advanced inflammatory and fibrogenic stage (non\u2010alcoholic steatohepatitis [NASH]). NASH affects a growing proportion of the global adult and pediatric population, leading to rising rates of liver fibrosis and hepatocellular carcinoma. NASH is a multifactorial disease that is part of a systemic metabolic disorder. Here, we provide an overview of the metabolic underpinnings of NASH pathogenesis and established drivers of inflammation and fibrosis. Clarification of underlying fibrogenic and inflammatory mechanisms will advance the development of novel treatment strategies as there are no approved therapies at present. We discuss emerging experimental approaches and potential novel investigational strategies derived from animal models including the inflammasome, epigenetic reprogramming, Hippo signaling, Notch signaling, engineered T cells to remove fibrogenic HSCs, and HSC\u2010specific targeting therapies. Recently completed and ongoing clinical trials and antifibrotics are discussed, illuminating the growing expectation that one or more therapies will yield clinical benefit in NASH in the coming years.<\/jats:p>","DOI":"10.1111\/joim.13380","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T16:44:51Z","timestamp":1632674691000},"page":"11-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Inflammatory and fibrotic mechanisms in NAFLD\u2014Implications for new treatment strategies"],"prefix":"10.1111","volume":"291","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6567-7755","authenticated-orcid":false,"given":"Youngmin A.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1178-6195","authenticated-orcid":false,"given":"Scott L.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Division of Liver Diseases Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.22942"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.08.011"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.05.057"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.07.019"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.043"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.043"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00271-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1844"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0093-z"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R067595"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.06.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.12.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128294"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.29"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29847"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2014.11.005"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29514"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.02.027"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.11.024"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.12.010"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.10.039"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e32835cc949"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2019.06.004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154203"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154342"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100237"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i34.5101"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1107"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.04.038"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.027"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.06.006"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13981"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.11.4"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-4025-x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1091141"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.162"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0001-6"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07976"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07338-z"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI91814"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.04.043"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140341"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.09.016"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.156307"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.008"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0215-7"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(18)30425-2"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08938"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.01.022"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320294111"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309575"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030522"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26775-w"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.97"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26746"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.05.020"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.01.007"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00054.2019"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150112103510"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39487"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42563"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz8455"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318918"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35653-4"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.141640"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2016.10.004"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0082-x"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.11"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2019.105922"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.001"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.013"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.10.024"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21065"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050503"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66025"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58789"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30655"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2007"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.38"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.10.026"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000056"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2017.11.004"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.04.003"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00153.2017"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.04.011"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.01.004"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30928"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0585-5"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0568"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.04.022"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat0344"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.060"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.009"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00033"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1546-z"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2403-9"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.12.013"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.033"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26093"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsec\/fiu002"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2112-9"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.08.018"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2017.1293224"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.09.008"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.031"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.07.006"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003051"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.07.007"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.04.032"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0269-9"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201809302"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12721"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3738"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmx009"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam9949"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800100-4.00003-9"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.02.018"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.85"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i8.677"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808567105"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2852"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.5.942"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0183-1"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03233-8"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08530"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-20-0018"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618804444"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307913"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41424-018-0025-4"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2011-1383"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1078"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114497"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12629-4"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043044"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210077"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0208"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.08.004"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800079-JLR200"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028395"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.102"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-2145"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32649-0"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.006"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.03.021"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2003697"},{"key":"e_1_2_10_149_1","first-page":"126688","article-title":"Sleeve gastrectomy rapidly enhances islet function independently of body weight","volume":"4","author":"Douros JD","year":"2019","journal-title":"JCI Insight"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1381\/0960892053923789"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.07.003"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122987"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00573.2012"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-11-200806030-00225"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.014"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.187"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32517-6"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1657"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa004"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129186"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S265286"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0104-9"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2020.0115"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30474-4"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30590"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31205"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.296"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2020.106170"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.023"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2019.105889"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.024"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13380","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joim.13380","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T15:40:39Z","timestamp":1693237239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.13380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,26]]},"references-count":171,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/joim.13380"],"URL":"https:\/\/doi.org\/10.1111\/joim.13380","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,26]]},"assertion":[{"value":"2021-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}