{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T01:01:59Z","timestamp":1784336519199,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about antineutrophil cytoplasmic antibodies (ANCA)\u2010associated vasculitis (AAV) in older patients. We aim to study relapse risk of granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) in patients diagnosed after 75\u00a0years and compare it with those of patients aged 65\u201375\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from AAV patients aged \u226565\u00a0years were extracted from the French Vasculitis Study Group (FVSG) database and from a call for observation to FVSG members. Cox and Fine\u2013Gray models were used to assess relapse risk, taking death into account either as a censoring or a competing event, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 219 patients aged \u226575\u00a0years (median 79) and 80 patients aged 65\u201375\u00a0years (median 70), of those 155 had GPA (52%), 136 MPA (45%), with 95 (32%) anti\u2010proteinase 3 positivity and 179 (61%) anti\u2010myeloperoxidase. Patients aged \u226575\u00a0years had a lower relapse risk in multivariate analysis (cause\u2010specific hazards ratio [CSHR] 0.54, 95% CI [0.33\u20130.89],<jats:italic>p<\/jats:italic>\u00a0=\u00a00.016, Cox model; subdistribution hazard ratio [SHR] 0.46, 95% CI [0.29\u20130.74],<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, Fine\u2013Gray model) after taking into account vasculitis type. Patients aged \u226575\u00a0years had a lower probability of being treated for remission maintenance with a combination of glucocorticoids and immunosuppressants (vs. glucocorticoids alone, HR 0.28, 95% CI [0.11\u20130.68],<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) after adjusting to Five Factor Score, although relapse\u2010free survival was significantly longer when receiving such combination (CSHR 0.40, 95% [CI 0.24\u20130.67],<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AAV patients \u226575\u00a0years have a lower relapse risk than patients aged 65\u201375\u00a0years despite a lower probability of having received maintenance therapy with a combination of glucocorticoids and immunosuppressants, but they still benefit from such treatment regimen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13417","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T12:18:26Z","timestamp":1636546706000},"page":"350-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Patients of 75\u00a0years and over with ANCA\u2010associated vasculitis have a lower relapse risk than younger patients: A multicentre cohort study"],"prefix":"10.1111","volume":"291","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1137-7247","authenticated-orcid":false,"given":"Sara","family":"Thietart","sequence":"first","affiliation":[{"name":"National Referral Center for Rare Systemic Autoimmune Diseases Department of Internal Medicine H\u00f4pital Cochin, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Paris France"},{"name":"APHP\u2010CUP H\u00f4pital Cochin Universit\u00e9 de Paris Paris 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