{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T20:22:40Z","timestamp":1786393360705,"version":"build-2736575974"},"reference-count":200,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["RTI2018\u2010094274\u2010B\u2010I00"],"award-info":[{"award-number":["RTI2018\u2010094274\u2010B\u2010I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2020\u2010118167RB\u2010I00"],"award-info":[{"award-number":["PID2020\u2010118167RB\u2010I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["810287"],"award-info":[{"award-number":["810287"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007232","name":"Radiumhemmets Forskningsfonder","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Careful histopathologic examination remains the cornerstone in the diagnosis of the clinically and biologically heterogeneous group of lymphoid malignancies. However, recent advances in genomic and epigenomic characterization using high\u2010throughput technologies have significantly improved our understanding of these tumors. Although no single genomic alteration is completely specific for a lymphoma entity, some alterations are highly recurrent in certain entities and thus can provide complementary diagnostic information when integrated in the hematopathological diagnostic workup. Moreover, other alterations may provide important information regarding the clinical course, that is, prognostic or risk\u2010stratifying markers, or response to treatment, that is, predictive markers, which may allow tailoring of the patient's treatment based on (epi)genetic characteristics. In this review, we will focus on clinically relevant diagnostic, prognostic, and predictive biomarkers identified in more common types of B\u2010cell malignancies, and discuss how diagnostic assays designed for comprehensive molecular profiling may pave the way for the implementation of precision diagnostics\/medicine approaches. We will also discuss future directions in this rapidly evolving field, including the application of single\u2010cell sequencing and other omics technologies, to decipher clonal dynamics and evolution in lymphoid malignancies.<\/jats:p>","DOI":"10.1111\/joim.13423","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T20:07:07Z","timestamp":1638907627000},"page":"221-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Towards precision medicine in lymphoid malignancies"],"prefix":"10.1111","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-3326","authenticated-orcid":false,"given":"Marco M.","family":"B\u00fchler","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Pathology University Hospital of Zurich  Zurich Switzerland"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Hematopathology Section Laboratory of Pathology Hospital Cl\u00ednic de Barcelona University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 I.","family":"Martin\u2010Subero","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Hematopathology Section Laboratory of Pathology Hospital Cl\u00ednic de Barcelona University of Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biomedica en Red de Cancer (CIBERONC)  Madrid Spain"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Pan\u2010Hammarstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Nutrition Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9850-9793","authenticated-orcid":false,"given":"Elias","family":"Campo","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Hematopathology Section Laboratory of Pathology Hospital Cl\u00ednic de Barcelona University of Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biomedica en Red de Cancer (CIBERONC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0211-8788","authenticated-orcid":false,"given":"Richard","family":"Rosenquist","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Clinical Genetics Karolinska University Laboratory Karolinska University Hospital  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12633"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.134510"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014209"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200710"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-692970"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.08.008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-020-00131-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2018.02.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0028-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-643361"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-01-765107"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2828"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02314"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1858-9"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.177"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15395"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14666"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10113"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012419-032810"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012283432602"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-10-764373"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002385"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005289"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9500"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017014860"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-500264"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2856"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-764365"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0098-8"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.127"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30029-8"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010021\u201003186\u20103"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-696757"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.330"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2759"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-359166"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.294"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.365"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120904"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012386"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2469"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08578-3"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2468"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001880"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11378"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055759"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.027"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801445"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0016-8"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80376-0"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.03.015"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003535"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-817601"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181f3e29f"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-20-0051"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002699"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-610436"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001012"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0541-6"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-812073"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-814913"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-704528"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001126"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282780"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.4482"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.125"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004492"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007039"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1913810117"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008311"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-3266"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-486209"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-017-0007-7"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.8762"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.187583"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.274"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-539726"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-659144"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-806398"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-373159"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109016"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1032"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.307"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08368.x"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.049270"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.359"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-395673"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.196"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-546150"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.229161"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00028-X"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-020-00418-4"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15519"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15518"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.7901"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.214056"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-838136"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30838"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-433334"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-129783"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-072082"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0007"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00169-2"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-212191"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.0985"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.4281"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215637"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509981"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315226"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-779736"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13361"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16088"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.187"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000635"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.110"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400029"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-06-719294"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-1119"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.155"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.109777"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.234716"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-664649"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2017.11.010"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2021.05.007"},{"key":"e_1_2_10_128_1","first-page":"3188","article-title":"Validation of the EuroClonality\u2010NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders","volume":"5","author":"Stewart JP","year":"2021","journal-title":"Blood Adv."},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024534"},{"key":"e_1_2_10_130_1","doi-asserted-by":"crossref","unstructured":"RosenquistRISRCTN \u2010 ISRCTN66987142: Evaluation of genome sequencing as a diagnostic test in acute leukemia.https:\/\/doi.org\/10.1186\/ISRCTN66987142","DOI":"10.1186\/ISRCTN66987142"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023075"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3230"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2013.08.001"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09906"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.05.032"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0128-0"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.08.010"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.01.024"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3291"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3488"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.01.017"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq513"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0073-4"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-10-r115"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2443"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000490"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2016.1178432"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000237"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.252"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.240721"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.09.014"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1615"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.180240.114"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3413"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1664-8"},{"key":"e_1_2_10_156_1","first-page":"585","article-title":"Identification of 2 DNA methylation subtypes of Waldenstr\u00f6m macroglobulinemia with plasma and memory B\u2010cell features","volume":"136","author":"Roos\u2010Weil D","year":"2020","journal-title":"Blood."},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature26000"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20603-4"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.11.001"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09645-5"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20188339"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11938"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010021\u201001389\u2010w"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20849-y"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.265520.120"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03695-8"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.018"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0355-0"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2019.11.010"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0420-2"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf2403"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/550451a"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay3224"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1652-y"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1373-2"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06318-7"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2797-4"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0468-5"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abe6291"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202489"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200483"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.06.013"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.602539"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.217331.116"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14081-6"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13182"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.10.005"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1198-z"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201021\u20100276"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13765"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0181-4"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-862292"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009855"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0532-x"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-0680"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0269-2"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0160-x"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-020-0053-3"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01232-w"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2020.0073"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22872-z"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joim.13423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T21:39:41Z","timestamp":1692826781000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.13423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":200,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/joim.13423"],"URL":"https:\/\/doi.org\/10.1111\/joim.13423","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,17]]},"assertion":[{"value":"2022-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}