{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:02:28Z","timestamp":1788469348397,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01316"],"award-info":[{"award-number":["PI17\/01316"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00079"],"award-info":[{"award-number":["PI20\/00079"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>(1) To evaluate clinical and molecular cardiovascular disease (CVD) signs and their relationship with psoriatic arthritis (PsA) features and (2) to identify a clinical patient profile susceptible to benefit from methotrexate (MTX) and\/or apremilast regarding CVD risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included 100 patients with PsA and 100 age\u2010matched healthy donors. In addition, an exploratory cohort of 45 biologically na\u00efve patients treated for 6 months with apremilast, MTX or combined therapy according to routine clinical practice was recruited. Extensive clinical and metabolic profiles were obtained. Ninety\u2010nine surrogate CVD\u2010related molecules were analysed in plasma and peripheral blood mononuclear cells (PBMCs). Hard cluster analysis was performed to identify the clinical and molecular phenotypes. Mechanistic studies were performed on adipocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cardiometabolic comorbidities were associated with disease activity and long\u2010term inflammatory status. Thirty\u2010five CVD\u2010related proteins were altered in the plasma and PBMCs of PsA patients and were associated with the key clinical features of the disease. Plasma levels of some of the CVD\u2010related molecules might distinguish insulin\u2010resistant patients (MMP\u20103, CD163, FABP\u20104), high disease activity (GAL\u20103 and FABP\u20104) and poor therapy outcomes (CD\u2010163, LTBR and CNTN\u20101). Hard cluster analysis identified two phenotypes of patients according to the rates of cardiometabolic comorbidities with distinctive clinical and molecular responses to each treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>(1) Novel CVD\u2010related proteins associated with clinical features could be emerging therapeutic targets in the context of PsA and (2) the pleiotropic action of apremilast could make it an excellent choice for the management of PsA patients with high CVD risk, targeting metabolic alterations and CVD\u2010related molecules.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13447","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T09:33:51Z","timestamp":1646213631000},"page":"676-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The clinical and molecular cardiometabolic fingerprint of an exploratory psoriatic arthritis cohort is associated with the disease activity and differentially modulated by methotrexate and apremilast"],"prefix":"10.1111","volume":"291","author":[{"given":"Ivan","family":"Arias de la Rosa","sequence":"first","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Dolores","family":"L\u00f3pez\u2010Montilla","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristobal","family":"Rom\u00e1n\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"P\u00e9rez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"G\u00f3mez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementina","family":"L\u00f3pez\u2010Medina","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lourdes","family":"Ladehesa\u2010Pineda","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria del Carmen","family":"\u00c1balos\u2010Aguilera","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra Maria","family":"Pati\u00f1o\u2010Trives","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Luque\u2010T\u00e9var","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"A\u00f1\u00f3n\u2010O\u00f1ate","sequence":"additional","affiliation":[{"name":"Rheumatology Department University Hospital of Jaen  Jaen Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jose","family":"P\u00e9rez\u2010Gal\u00e1n","sequence":"additional","affiliation":[{"name":"Rheumatology Department University Hospital of Jaen  Jaen Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Guzm\u00e1n\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Malag\u00f3n","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-4603","authenticated-orcid":false,"given":"Chary","family":"L\u00f3pez\u2010Pedrera","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Escudero\u2010Contreras","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Collantes\u2010Est\u00e9vez","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0962-6072","authenticated-orcid":false,"given":"Nuria","family":"Barbarroja","sequence":"additional","affiliation":[{"name":"Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)\/Reina Sofia Hospital University of Cordoba  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30830-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40726"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2019.12.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622320965067"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201194"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23171"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108397"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128262"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1740593"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.06.019"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5380792"},{"key":"e_1_2_8_13_1","first-page":"17","article-title":"Local effects of adipose tissue in psoriasis and psoriatic arthritis","volume":"7","author":"Kruglikov IL","year":"2017","journal-title":"Psoriasis (Auckl)."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2017.11.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0709-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1439-1"},{"key":"e_1_2_8_17_1","article-title":"Methotrexate for psoriatic arthritis","volume":"18","author":"Wilsdon TD","year":"2019","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2369-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0302-0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_8_22_1","volume-title":"BMI classification percentile and cut off points","author":"Weir CB","year":"2021"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01643.x"},{"key":"e_1_2_8_24_1","first-page":"757","article-title":"Lipoprotein ratios: physiological significance and clinical usefulness in cardiovascular prevention","volume":"5","author":"Mill\u00e1n J","year":"2009","journal-title":"Vasc Health Risk Manag."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.36"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr424"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12743"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.01.012"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0256-0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/OARRR.S206931"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken090"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179737"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04284.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05131.x"},{"key":"e_1_2_8_35_1","article-title":"Galectins in the pathogenesis of rheumatoid arthritis","volume":"4","author":"Li S","year":"2013","journal-title":"J Clin Cell Immunol."},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2020-0284"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-016-4211-4"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/lipd.12173"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01963.x"},{"key":"e_1_2_8_40_1","first-page":"689","article-title":"Soluble macrophage\u2010derived CD163 is a marker of disease activity and progression in early rheumatoid arthritis","volume":"29","author":"Greisen SR","year":"2011","journal-title":"Clin Exp Rheumatol."},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2021.1932461"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12385"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207963"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14164"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15293"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8030398"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab474"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joim.13447","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:11:47Z","timestamp":1692965507000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.13447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,2]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/joim.13447"],"URL":"https:\/\/doi.org\/10.1111\/joim.13447","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,2]]},"assertion":[{"value":"2022-03-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}