{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:30:35Z","timestamp":1782552635906,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammation of unknown origin (IUO) is a challenging situation in internal medicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the final diagnoses in IUO and assess the helpfulness of <jats:sup>18<\/jats:sup>F\u2010fluorodesoxyglucose positron emission tomography with computerized tomography (<jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET\/CT) in the diagnosis strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 317 IUO patients with <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET\/CT were enrolled. A diagnosis was reached in 228 patients: noninfectious inflammatory diseases (NIID) (37.5%), infectious diseases (18.6%), malignancies (7.9%), and non\u2010systemic\u2010inflammatory miscellaneous diseases (7.9%). The two leading causes of NIID were polymyalgia rheumatica and giant cell arteritis. <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET\/CT results were classified as true positive in 49.8% of patients and contributory in 75.1% of overall IUO patients (after the complete investigation set and a prolonged follow\u2010up). In multivariate analysis, only C\u2010reactive protein minimum level (\u226550\u00a0mg\/L) was associated with the contributory status of <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET\/CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the wide spectrum of IUO underlying diseases, <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET\/CT is helpful to make a diagnosis and to eliminate inflammatory diseases. Obese patients constitute a specific group needing further studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13452","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T01:50:08Z","timestamp":1641952208000},"page":"856-863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Diagnostic performance of <sup>18<\/sup>F\u2010FDG\u2010PET\/CT in inflammation of unknown origin: A clinical series of 317 patients"],"prefix":"10.1111","volume":"291","author":[{"given":"Jan","family":"Holubar","sequence":"first","affiliation":[{"name":"Internal Medicine Department CHU N\u00eemes University of Montpellier  N\u00eemes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Broner","sequence":"additional","affiliation":[{"name":"Internal Medicine Department CHU N\u00eemes University of Montpellier  N\u00eemes 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