{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:33:15Z","timestamp":1791005595093,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary arterial hypertension (PAH) is an independent predictor of death in patients with human immunodeficiency virus (HIV) infection. HIV is the leading cause of PAH (HIV\u2010PAH) worldwide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We described the characteristics, treatment patterns, and prognosis of a cohort of HIV\u2010PAH patients and compared them with those of an equivalent cohort of patients with idiopathic\/familial PAH (IPAH\/FPAH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed and compared the demographic, clinical, and treatment data from patients with HIV\u2010PAH and those with IPAH\/FPAH in the Spanish PAH registry (REHAP) from 1998 to 2018. The HIV\u2010PAH overall survival (OS) rate up to 5 years was compared to the age\u2010 and sex\u2010matched IPAH\/FPAH population. Changes in treatment patterns in patients with HIV\u2010PAH after 2010 and their effects on OS were also analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to those with IPAH\/FPAH (<jats:italic>n<\/jats:italic> = 739), patients with HIV\u2010PAH (<jats:italic>n<\/jats:italic> = 132) were younger, mainly men, and had a better functional status. The clinical presentation, haemodynamics, and respiratory function were similar between the groups. Parenteral drug use was the most common mode of HIV transmission. Approximately 11% of patients with HIV\u2010PAH did not receive PAH\u2010targeted therapy. The age\u2010 and sex\u2010adjusted 5\u2010year OS rate from diagnosis was 74.0% for patients with HIV\u2010PAH and 68.7% for those with IPAH (<jats:italic>p<\/jats:italic> &lt; 0.159). During\/after 2010, 23% of patients with IPAH\/FPAH received upfront dual oral combination, while oral monotherapy remained the main first\u2010line treatment in patients with HIV\u2010PAH. The overall OS rate remained stable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with HIV\u2010PAH were predominantly young men. The short\u2010term prognosis is similar to that of age\u2010 and sex\u2010matched patients with IPAH\/FPAH, despite a better functional status. Oral monotherapy remains the preferred first\u2010line treatment in the current cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13468","type":"journal-article","created":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T19:39:30Z","timestamp":1645385970000},"page":"116-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Management and prognosis of HIV\u2010associated pulmonary arterial hypertension: 20 Years of evidence from the REHAP registry"],"prefix":"10.1111","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-4977","authenticated-orcid":false,"given":"Mar\u00eda L\u00e1zaro","family":"Salvador","sequence":"first","affiliation":[{"name":"Department of Cardiology Hospital Universitario de Toledo  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Rodr\u00edguez\u2010Padial","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario de Toledo  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Soto Ab\u00e1nades","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Cruz Utrilla","sequence":"additional","affiliation":[{"name":"Pulmonary Hypertension Unit, Department of Cardiology Hospital Universitario 12 de Octubre. 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