{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:00:10Z","timestamp":1782439210671,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T00:00:00Z","timestamp":1646524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to present a novel clinical manifestation of infection with the Omicron variant of the SARS\u2010CoV\u20102 virus affecting mainly young, vaccinated, and healthy adults. We describe a new group of COVID\u201019 patients seeking emergency care with symptoms similar to the life\u2010threatening condition epiglottitis. Here, we present a case series and discuss management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective single\u2010center case study of patients diagnosed with COVID\u201019 who were referred to the Ear, Nose, and Throat Emergency Department (ENT ED) between January 1 and January 23, 2022 with clinical symptoms such as acute odynophagia, severe sore throat, and fever. Ethical approval was obtained from the Swedish Ethical Review Authority (2020\u201002579). Informed consent was obtained from all patients included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients meeting inclusion criteria were identified. Fifteen patients were fully vaccinated against COVID\u201019. Four patients needed a short hospitalization for their symptoms. The most common diagnoses were COVID\u201019\u2010associated acute viral laryngotracheitis and\/or viral pharyngitis. Six patients presented with signs of secondary bacterial infection and were put on antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Previous variants of SARS\u2010CoV\u20102 infection affected predominantly the lower respiratory tract and were associated with loss of smell and taste in many patients. The Omicron variant seems to affect predominantly the upper airways and cause acute laryngitis without olfactory dysfunction. In some patients, the clinical manifestation is similar to the symptoms of epiglottitis. In such a case, a prompt examination of the larynx is the gold standard to exclude inflammatory edema in the upper airways. None of the patients described in this study developed epiglottitis. In this study, we discuss the management of acute odynophagia in COVID\u201019 patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13470","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T05:39:12Z","timestamp":1644989952000},"page":"154-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Acute odynophagia: A new symptom of COVID\u201019 during the SARS\u2010CoV\u20102 Omicron variant wave in Sweden"],"prefix":"10.1111","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3711-8371","authenticated-orcid":false,"given":"Krzysztof","family":"Piersiala","sequence":"first","affiliation":[{"name":"Department of ENT Diseases Karolinska University Hospital  Stockholm Sweden"},{"name":"Division of ENT Diseases Department of Clinical Science Intervention and Technology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Kakabas","sequence":"additional","affiliation":[{"name":"Department of ENT Diseases Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bruckova","sequence":"additional","affiliation":[{"name":"Department of ENT Diseases Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Starkhammar","sequence":"additional","affiliation":[{"name":"Department of ENT Diseases Karolinska University Hospital  Stockholm Sweden"},{"name":"Division of ENT Diseases Department of Clinical Science Intervention and Technology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Olaf","family":"Cardell","sequence":"additional","affiliation":[{"name":"Department of ENT Diseases Karolinska University Hospital  Stockholm Sweden"},{"name":"Division of ENT Diseases Department of Clinical Science Intervention and Technology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,6]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO. WHO coronavirus (COVID\u201019) dashboard.2022. Available from:https:\/\/covid19.who.int\/. Accessed 29 Jan 2022."},{"key":"e_1_2_8_3_1","unstructured":"WHO. Update on omicron. 2021. Available from:https:\/\/www.who.int\/news\/item\/28\u201011\u20102021\u2010update\u2010on\u2010omicron. Accessed 29 Jan 2022."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.12.08.21267494"},{"key":"e_1_2_8_5_1","volume-title":"Report 49: Growth, population distribution and immune escape of Omicron in England","author":"Ferguson Ghani A","year":"2021"},{"key":"e_1_2_8_6_1","unstructured":"Omicron and cold\u2010like symptoms rapidly taking over in London. [cited Dec 2021]. Available from:https:\/\/covid.joinzoe.com\/post\/omicron\u2010and\u2010cold\u2010like\u2010symptoms\u2010rapidly\u2010taking\u2010over\u2010in\u2010london."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2021.26.50.2101146"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n3144"},{"key":"e_1_2_8_9_1","unstructured":"Vecka 52 2021 \u2013 Statistik om f\u00f6rekomst av misst\u00e4nkta fall av SARS\u2010CoV\u20102 virusvarianten omikron. Available from:https:\/\/www.folkhalsomyndigheten.se\/smittskydd\u2010beredskap\/utbrott\/aktuella\u2010utbrott\/covid\u201019\/statistik\u2010och\u2010analyser\/sars\u2010cov\u20102\u2010virusvarianter\u2010av\u2010sarskild\u2010betydelse\/statistik\u2010om\u2010forekomst\u2010av\u2010misstankta\u2010fall\u2010av\u2010sars\u2010cov\u20102\u2010virusvarianten\u2010omikron\/vecka\u201052\u20102021\/. 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