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The GWAS of HDL\u2010CEC was carried out in 20,372 participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HDL\u2010CEC did not associate with CHD when adjusted for traditional risk factors and HDL cholesterol (HDL\u2010C). In contradiction, almost all HDL\u2010related concentration measures associated consistently with CHD after corresponding adjustments. There were no genetic loci associated with HDL\u2010CEC independent of HDL\u2010C and triglycerides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HDL\u2010CEC is not unequivocally associated with CHD in contrast to HDL\u2010C, apolipoprotein A\u2010I, and most of the HDL subclass particle concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13479","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T10:43:23Z","timestamp":1647341003000},"page":"146-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genetic and observational evidence: No independent role for cholesterol efflux over static high\u2010density lipoprotein concentration measures in coronary heart disease risk assessment"],"prefix":"10.1111","volume":"292","author":[{"given":"Sanna","family":"Kuusisto","sequence":"first","affiliation":[{"name":"Computational Medicine Faculty of Medicine University of Oulu  Oulu Finland"},{"name":"Center for Life Course Health Research Faculty of Medicine University of Oulu  Oulu Finland"},{"name":"NMR Metabolomics Laboratory School of Pharmacy University of Eastern Finland  Kuopio Finland"},{"name":"Biocenter Oulu University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna K.","family":"Karjalainen","sequence":"additional","affiliation":[{"name":"Computational Medicine Faculty of Medicine University of Oulu  Oulu Finland"},{"name":"Center for Life Course Health Research Faculty of Medicine University of Oulu  Oulu Finland"},{"name":"Biocenter Oulu University of Oulu  Oulu Finland"},{"name":"Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies Faculty of Medicine University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"Tillin","sequence":"additional","affiliation":[{"name":"MRC Unit for Lifelong Health and Ageing at UCL Institute of Cardiovascular Science University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti J.","family":"Kangas","sequence":"additional","affiliation":[{"name":"Nightingale Health Plc.  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