{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:15:13Z","timestamp":1791915313005,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prosthetic valve endocarditis (PVE) is a feared complication after heart valve surgery. Studies on differences in bacteriology in various types of PVE are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to investigate the microbiology of PVE depending on the type of prosthetic valve and timing of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study based on the Swedish Registry on Infective Endocarditis focusing on PVE was conducted. The cohort was divided into mechanical and bioprosthetic valves; into endocarditis localization in the aortic, mitral, or tricuspid valve; and into early and late PVE. The microbiology in these groups was compared. Predictors of <jats:italic>Staphylococcus aureus<\/jats:italic> as the cause of PVE were examined by multivariable logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 780 episodes of PVE in 749 patients were compared regarding the distribution of causative microbiological agents. The most common agents included alpha\u2010hemolytic streptococci (29%), <jats:italic>S. aureus<\/jats:italic> (22%), enterococci (14%), coagulase\u2010negative staphylococci (CoNS) (12%), and <jats:italic>Cutibacterium acnes<\/jats:italic> (6%). <jats:italic>S. aureus<\/jats:italic> was more commonly found on mechanical valves compared to bioprosthetic ones (36% vs. 17%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) whereas alpha\u2010hemolytic streptococci, enterococci, and CoNS were more common on bioprosthetic valves. There were no significant differences in the microbiology of PVE affecting mitral or aortic valves or in cases of early and late PVE. Predictors for <jats:italic>S. aureus<\/jats:italic> as the cause of PVE were end\u2010stage renal disease, intravenous drug use, mechanical valve, and tricuspid localization of endocarditis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The type of prosthetic heart valve is associated with the causative pathogen. Patients with mechanical valves are more likely to have PVE caused by <jats:italic>S. aureus<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13491","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T09:36:32Z","timestamp":1649064992000},"page":"428-437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Microbiological etiology in prosthetic valve endocarditis: A nationwide registry study"],"prefix":"10.1111","volume":"292","author":[{"given":"Blerand","family":"Berisha","sequence":"first","affiliation":[{"name":"Division of Infection Medicine Department of Clinical Sciences Lund Lund University  Lund Sweden"},{"name":"Department for Infectious Diseases Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurdur","family":"Ragnarsson","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery Department for Clinical Sciences Lund Skane University Hospital and Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Olaison","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Institute of Biomedicine University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1588-5473","authenticated-orcid":false,"given":"Magnus","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Division of Infection Medicine Department of Clinical Sciences Lund Lund University  Lund Sweden"},{"name":"Department for Infectious Diseases Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv319"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.12.1354"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2016.08.09"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx169"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.11.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.12.017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2018-000926"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-017-3172-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/313753"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy153"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(81)90071-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.08.042"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.5772\/65030"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz588"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13491","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joim.13491","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T23:08:53Z","timestamp":1692832133000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.13491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,19]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/joim.13491"],"URL":"https:\/\/doi.org\/10.1111\/joim.13491","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,19]]},"assertion":[{"value":"2022-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}