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Serum levels of infliximab and ADAb were measured at each infusion. Possible risk factors for ADAb formation were assessed using logistic regression, adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ADAb were detected in 78 (19%) patients. A diagnosis of rheumatoid arthritis (RA) (odds ratio [OR], 1.9 [95% confidence interval [CI] 1.0\u20133.6]) and lifetime smoking (OR, 2.0 [CI 1.1\u20133.6]) were baseline risk factors, while baseline use of concomitant immunosuppressors (OR, 0.4 [CI 0.2\u20130.8]) and a diagnosis of spondyloarthritis (SpA) (OR, 0.4 [CI 0.2\u20130.8]) reduced the risk of ADAb. Higher disease activity during follow\u2010up (OR, 1.1 [CI 1.0\u20131.1]) and \u201cdrug holidays\u201d of more than 11\u00a0weeks (OR, 4.1 [CI 1.2\u201313.8]) increased the risk of ADAb, whereas higher infliximab doses (OR, 0.1 [CI 0.0\u20130.3) and higher serum infliximab concentrations (OR, 0.7 [CI 0.6\u20130.8]) reduced the risk of immunogenicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Several risk factors for ADAb formation during early\u2010phase infliximab treatment were identified. This knowledge provides a basis for treatment strategies to mitigate the formation of ADAb and identify patients in whom these measures are of particular importance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13495","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T09:21:19Z","timestamp":1649755279000},"page":"477-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Risk factors for anti\u2010drug antibody formation to infliximab: Secondary analyses of a randomised controlled trial"],"prefix":"10.1111","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5148-9684","authenticated-orcid":false,"given":"Marthe Kirkes\u00e6ther","family":"Brun","sequence":"first","affiliation":[{"name":"Division of Rheumatology and Research Diakonhjemmet Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo 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