{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:09:17Z","timestamp":1772208557914,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) breakthrough infections are common.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Evaluate in\u2010hospital mortality of patients with COVID\u201019 by vaccination status using retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We generated propensity scores for receipt of full vaccination in adults requiring supplemental oxygen hospitalized at Kaiser Permanente Northern California (1 April 2021 to 30 November 2021) with positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction tests. Optimal matching of fully vaccinated\/unvaccinated patients was performed comparing in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 7305 patients, 1463 (20.0%) were full, 138 (1.9%) were partial, and 5704 (78.1%) were unvaccinated. Fully vaccinated were older than partial or unvaccinated (71.0, 63.0, and 54.0 years, respectively, <jats:italic>p<\/jats:italic> &lt; 0.001) with more comorbidities (Comorbidity Point Scores 33.0, 22.0, and 10.0, <jats:italic>p<\/jats:italic> &lt; 0.001) and immunosuppressant (11.5%, 8.7%, and 3.0%, <jats:italic>p<\/jats:italic> &lt; 0.001) or chemotherapy exposure (2.8%, 0.7%, and 0.4%, <jats:italic>p<\/jats:italic> &lt; 0.001). Fewer fully vaccinated patients died compared to matched unvaccinated (9.0% vs. 16.3%, <jats:italic>p<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fully vaccinated patients are less likely to die compared to matched unvaccinated patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13504","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T08:24:30Z","timestamp":1652084670000},"page":"377-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Adults hospitalized with breakthrough COVID\u201019 have lower mortality than matched unvaccinated adults"],"prefix":"10.1111","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-3388","authenticated-orcid":false,"given":"Laura C.","family":"Myers","sequence":"first","affiliation":[{"name":"Division of Research and The Permanente Medical Group Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Kipnis","sequence":"additional","affiliation":[{"name":"Division of Research and The Permanente Medical Group Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Greene","sequence":"additional","affiliation":[{"name":"Division of Research and The Permanente Medical Group Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Lawson","sequence":"additional","affiliation":[{"name":"Division of Research and The Permanente Medical Group Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel J.","family":"Escobar","sequence":"additional","affiliation":[{"name":"Division of Research and The Permanente Medical Group Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce H.","family":"Fireman","sequence":"additional","affiliation":[{"name":"Division of Research and The Permanente Medical Group Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola P.","family":"Klein","sequence":"additional","affiliation":[{"name":"Division of Research and The Permanente Medical Group Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent X.","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Research and The Permanente Medical Group Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2110362"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2101544"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00947\u20108"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7021e3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7034e1"},{"key":"e_1_2_10_9_1","unstructured":"Centers for Disease Control and Prevention.When you've been fully vaccinated.https:\/\/www.cdc.gov\/coronavirus\/2019\u2010ncov\/vaccines\/fully\u2010vaccinated.html#vaccinated(2021). 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