{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T19:10:48Z","timestamp":1774552248385,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20210114"],"award-info":[{"award-number":["20210114"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Dyspnea is common after COVID\u201019. Though the underlying mechanisms are largely unknown, lung perfusion abnormalities could contribute to lingering dyspnea.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To detect pulmonary perfusion disturbances in nonhospitalized individuals with the post\u2010COVID condition and persistent dyspnea 4\u201313 months after the disease onset.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Individuals with dyspnea and matched healthy controls were recruited for dynamic contrast\u2010enhanced magnetic resonance imaging (DCE\u2010MRI), a 6\u2010min walk test, and an assessment of dyspnea. The DCE\u2010MRI was quantified using two parametric values: mean time to peak (TTP) and TTP ratio, reflecting the total lung perfusion resistance and the fraction of lung with delayed perfusion, respectively.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty\u2010eight persons with persistent dyspnea (mean age 46.5\u00a0\u00b1\u00a08.0 years, 75% women) and 22 controls (mean age 44.1\u00a0\u00b1\u00a010.8 years, 73% women) were included. There was no systematic sex difference in dyspnea. The post\u2010COVID group had no focal perfusion deficits but had higher mean pulmonary TTP (0.43\u00a0\u00b1\u00a00.04 vs. 0.41\u00a0\u00b1\u00a00.03,\n p<\/jats:italic>\n = 0.011) and TTP ratio (0.096\u00a0\u00b1\u00a00.052 vs. 0.068\u00a0\u00b1\u00a00.027,\n p<\/jats:italic>\n = 0.032). Post\u2010COVID males had the highest mean TTP of 0.47\u00a0\u00b1\u00a00.02 and TTP ratio of 0.160\u00a0\u00b1\u00a00.039 compared to male controls and post\u2010COVID females (\n p<\/jats:italic>\n = 0.001 and\n p<\/jats:italic>\n \u00a0<\u00a00.001, respectively). Correlations between dyspnea and perfusion parameters were demonstrated in males (\n r<\/jats:italic>\n = 0.83,\n p<\/jats:italic>\n \u00a0<\u00a00.001 for mean TTP;\n r<\/jats:italic>\n = 0.76,\n p<\/jats:italic>\n = 0.003 for TTP ratio), but not in females.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n DCE\u2010MRI demonstrated late contrast bolus arrival in males with post\u2010COVID dyspnea, suggestive of primary vascular lesions or secondary effects of hypoxic vasoconstriction. Since this effect was not regularly observed in female patients, our findings suggest sex differences in the mechanisms underlying post\u2010COVID dyspnea, which warrants further investigation in dedicated trials.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/joim.13558","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T08:19:25Z","timestamp":1660119565000},"page":"941-956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Lung perfusion disturbances in nonhospitalized post\u2010COVID with dyspnea\u2014A magnetic resonance imaging feasibility study"],"prefix":"10.1111","volume":"292","author":[{"given":"Jimmy Z.","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Radiology Solna Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm 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