{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:37:41Z","timestamp":1789544261824,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970161"],"award-info":[{"award-number":["81970161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170215"],"award-info":[{"award-number":["82170215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The heterogeneity of relapsed or refractory (R\/R) acute myeloid leukemia (AML) leads to no response to venetoclax (VEN)\u2013based therapy in more than half of the patients. Genetic characteristics are considered important predictors for response to treatment in adults with AML. However, the association of genetic characteristics with outcomes receiving VEN\u2010based therapy is incompletely understood in R\/R AML.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy of VEN combined with hypomethylating agents (HMA) and identify the potential genetic predictors of response in R\/R AML.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 150 R\/R AML patients treated with VEN combined with HMA were enrolled in this retrospective study. Outcomes of the response and overall survival (OS) were analyzed. The predictors of response and OS were analyzed by logistic regression or Cox proportional hazards model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With a median of two (range, 1\u20134) cycles of therapy, the overall response rate was 56.2%, including 22.0% complete remission (CR), 21.3% CR with incomplete hematologic recovery, 2.0% morphologic leukemia\u2010free state, and 10.7% partial remission, in which 25 patients achieved measurable residual disease (MRD)\u2013negative response. With a median follow\u2010up of 11.2 [95% confidence interval (CI), 7.2\u201314.8] months, 1\u2010 and 2\u2010year OS were 46.9% (95% CI, 37.8%\u201358.1%) and 38.9% (95% CI, 28.7%\u201352.9%), respectively. Adverse cytogenetics and European Leukemia Net (ELN) risk predicted inferior response to VEN\u2010based therapy. Mutations in IDH1\/2, NPM1, ASXL1, and chromatin\u2013cohesin genes predicted superior response to VEN\u2010based therapy, whereas mutations in active signaling genes such as FLT3\u2010ITD and K\/NRAS predicted inferior response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>VEN combined with HMA was effective with R\/R AML patients, and the response to treatment was associated with genetic characteristics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.13581","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:58:07Z","timestamp":1666745887000},"page":"329-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Genetic characteristics predict response to venetoclax plus hypomethylating agents in relapsed or refractory acute myeloid leukemia"],"prefix":"10.1111","volume":"293","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7923-8972","authenticated-orcid":false,"given":"Guangyang","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Hematology Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"Department of Hematology The First Affiliated Hospital of Shenzhen University Shenzhen Second People's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guopan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanfang Hospital Southern Medical University  Guangzhou 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