{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:20:44Z","timestamp":1790799644314,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T00:00:00Z","timestamp":1670716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on long\u2010term cardiovascular outcomes in primary Sj\u00f6gren's syndrome (PSS) are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aim to investigate the long\u2010term rate of incident heart failure (HF) and other adverse cardiovascular endpoints in patients with PSS compared with the general population and to investigate mortality in individuals with incident HF with or without a history of PSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using Danish nationwide registries, PSS patients (diagnosed 1996\u20132018) without a history of other autoimmune diseases were each matched with four individuals from the general population by sex, age, and comorbidities. Multivariable Cox regression was used to estimate the rate of cardiovascular outcomes. In addition, the rate of death from any cause was compared between PSS patients with incident HF and four age\u2010 and sex\u2010matched HF patients without PSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 5092 patients with newly diagnosed PSS were matched with 20,368 individuals from the general population (median age 57 years, 87.3% women, median follow\u2010up 7.4 years). The cumulative incidence of HF at 10 years was 4.0% for PSS patients and 2.8% for matched individuals. After adjustment, patients with PSS had a higher associated rate of incident HF (hazard ratios [HR] 1.42 [95% CI, 1.20\u20131.68]) and other cardiovascular outcomes, compared with the background population. PSS patients with incident HF had a similar rate of death from all\u2010cause mortality compared with HF patients without PSS (HR 0.94 [0.74\u20131.19]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with PSS had a higher associated rate of incident HF and other cardiovascular outcomes compared with the general population. In individuals with incident HF, a history of PSS was not associated with increased mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13595","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T06:14:22Z","timestamp":1670825662000},"page":"457-469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Long\u2010term risk of heart failure and other adverse cardiovascular outcomes in primary Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"293","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8888-379X","authenticated-orcid":false,"given":"Guoli","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil L.","family":"Fosb\u00f8l","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3889-0080","authenticated-orcid":false,"given":"Adelina","family":"Yafasova","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel","family":"Faurschou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Lindhardsen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nordsj\u00e6llands Hospital Hiller\u00f8d Denmark and Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawad H.","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66990-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.02.029"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014661"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.06.038"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00817"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5606\/ArchRheumatol.2018.6492"},{"key":"e_1_2_8_8_1","first-page":"124","article-title":"Primary Sj\u00f6gren's syndrome and the risk of acute myocardial infarction: a nationwide study","volume":"29","author":"Chiang C","year":"2013","journal-title":"Acta Cardiol Sin."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2573-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318756287"},{"key":"e_1_2_8_11_1","first-page":"71","article-title":"Risk of Cardiovascular involvement in patients with primary Sj\u00f6gren's syndrome: a large\u2010scale cross\u2010sectional cohort study","volume":"44","author":"Cai X","year":"2019","journal-title":"Acta Reumatol Port."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12346"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23821"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.963462"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.08.074"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394715"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811405098"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.720847"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d124"},{"key":"e_1_2_8_24_1","article-title":"The validity of the diagnosis of heart failure (I50.0\u2010I50.9) in the Danish National Patient Register","volume":"65","author":"Delekta J","year":"2018","journal-title":"Dan Med J."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012817"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012832"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-11-83"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2008.05.006"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1475-x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090942"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31820a91b9"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161118666200129125320"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000426"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.821306"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.25"},{"key":"e_1_2_8_36_1","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich PA","year":"2022","journal-title":"Circulation."},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.03.017"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-019-02060-0"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv316"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209687"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12941"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61306-8"},{"key":"e_1_2_8_43_1","first-page":"109","article-title":"Is the heart affected in primary Sj\u00f6gren's syndrome? An echocardiographic study","volume":"26","author":"Vassiliou V","year":"2008","journal-title":"Clin Exp Rheumatol."},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3278"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2020.1807598"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/egnd1i"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joim.13595","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:26:24Z","timestamp":1695018384000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.13595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,11]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/joim.13595"],"URL":"https:\/\/doi.org\/10.1111\/joim.13595","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,11]]},"assertion":[{"value":"2022-12-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}