{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:36:52Z","timestamp":1790804212643,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T00:00:00Z","timestamp":1677369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012446","name":"Akershus Universitetssykehus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Immunogenicity to tumour necrosis factor inhibitors is a significant clinical problem leading to treatment failure and adverse events. The study aimed to assess human leukocyte antigen (HLA) associations with anti\u2010drug antibody (ADAb) formation to infliximab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immune\u2010mediated inflammatory disease patients on infliximab therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a0612) were included. Neutralising ADAb were assessed with a drug\u2010sensitive assay. Next generation sequencing\u2010based HLA typing was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 147 (24%) patients\u00a0developed ADAb. Conditional analyses indicated <jats:italic>HLA\u2010DQB1<\/jats:italic> (<jats:italic>p<\/jats:italic>\u00a0=\u00a01.4\u00a0\u00d7\u00a010<jats:sup>\u22126<\/jats:sup>) as a primary risk locus. Highest risk of ADAb was seen when carrying at least one of the HLA\u2010DQ2 haplotypes; DQB1*02:01\u2013DQA1*05:01 or DQB1*02:02\u2013DQA1*02:01 (OR 3.18, 95% CI 2.15\u20134.69 and <jats:italic>p<\/jats:italic>\u00a0=\u00a05.9\u00a0\u00d7\u00a010<jats:sup>\u22129<\/jats:sup>). Results were consistent across diseases and when adjusting for concomitant immunomodulator. Computational predictions indicated that these HLA\u2010DQ2 haplotypes bind to peptide motifs from infliximab light chain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A genome\u2010wide significant association between two HLA\u2010DQ2 haplotypes and the risk of ADAb formation to infliximab was identified, suggesting that HLA\u2010DQ2 testing may facilitate personalised treatment decisions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13616","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T06:30:52Z","timestamp":1677479452000},"page":"648-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["HLA\u2010DQ2 is associated with anti\u2010drug antibody formation to infliximab in patients with immune\u2010mediated inflammatory diseases"],"prefix":"10.1111","volume":"293","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5148-9684","authenticated-orcid":false,"given":"Marthe Kirkes\u00e6ther","family":"Brun","sequence":"first","affiliation":[{"name":"Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY) Diakonhjemmet Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2369-6760","authenticated-orcid":false,"given":"Kristin Hammersb\u00f8en","family":"Bj\u00f8rlykke","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Department of Gastroenterology Akershus University Hospital  L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-9269","authenticated-orcid":false,"given":"Marte 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