{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:15:45Z","timestamp":1793106945666,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013295","name":"Helmholtz Zentrum M\u00fcnchen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013295","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary aldosteronism (PA) is a frequent cause of hypertension. Aldosterone excess together with high dietary salt intake aggravates cardiovascular damage, despite guideline\u2010recommended mineralocorticoid receptor antagonist (MRA) treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the antihypertensive impact of a moderate dietary salt restriction and associated physiological changes, including mental well\u2010being.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 41 patients with PA on a stable antihypertensive regimen\u2014including MRA\u2014followed a dietary salt restriction for 12 weeks with structured nutritional training and consolidation by a mobile health app. Salt intake and adherence were monitored every 4 weeks using 24\u2010h urinary sodium excretion and nutrition protocols. Body composition was assessed by bioimpedance analysis and mental well\u2010being by validated questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dietary salt intake significantly decreased from 9.1 to 5.2\u00a0g\/d at the end of the study. In parallel, systolic (130 vs. 121\u00a0mm\u00a0Hg) and diastolic blood pressure (BP) (84 vs. 81\u00a0mm\u00a0Hg) improved significantly. Patients\u2019 aptitude of estimating dietary salt content was refined significantly (underestimation by 2.4 vs. 1.4\u00a0g\/d). Salt restriction entailed a significant weight loss of 1.4\u00a0kg, improvement in pulse pressure (46 vs. 40\u00a0mm\u00a0Hg) and normalization of depressive symptoms (PHQD scale,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Salt restriction, cortisol after dexamethasone suppression test and dosage of renin\u2010angiotensin\u2010aldosterone\u2010system (RAAS) blockers were independently associated with BP reduction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A moderate restriction of dietary salt intake in patients with PA substantially reduces BP and depressive symptoms. Moreover, the findings underline that a sufficient RAAS blockade seems to augment the effects of salt restriction on BP and cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.13618","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T03:05:13Z","timestamp":1679454313000},"page":"47-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Moderate dietary salt restriction improves blood pressure and mental well\u2010being in patients with primary aldosteronism: The salt CONNtrol trial"],"prefix":"10.1111","volume":"294","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-0951","authenticated-orcid":false,"given":"Holger","family":"Schneider","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen  Munich 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