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Infection with severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), a cytolytic respiratory RNA virus, can lead to acute hypoxemic COVID\u201019 pneumonia in children with inborn errors of type I interferon (IFN) immunity or autoantibodies against IFNs. These patients do not appear to be prone to severe disease during infection with Epstein\u2013Barr virus (EBV), a leukocyte\u2010tropic DNA virus that can establish latency. By contrast, various forms of severe EBV disease, ranging from acute hemophagocytosis to chronic or long\u2010term illnesses, such as agammaglobulinemia and lymphoma, can manifest in children with inborn errors disrupting specific molecular bridges involved in the control of EBV\u2010infected B cells by cytotoxic T cells. The patients with these disorders do not seem to be prone to severe COVID\u201019 pneumonia. These experiments of nature reveal surprising levels of redundancy of two different arms of immunity, with type I IFN being essential for host defense against SARS\u2010CoV\u20102 in respiratory epithelial cells, and certain surface molecules on cytotoxic T cells essential for host defense against EBV in B lymphocytes.<\/jats:p>","DOI":"10.1111\/joim.13628","type":"journal-article","created":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T15:59:10Z","timestamp":1678636750000},"page":"127-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Human genetic and immunological determinants of SARS\u2010CoV\u20102 and Epstein\u2013Barr virus diseases in childhood: Insightful contrasts"],"prefix":"10.1111","volume":"294","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1990-8804","authenticated-orcid":false,"given":"Qiang","family":"Pan\u2010Hammarstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of 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