{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T06:55:38Z","timestamp":1781938538013,"version":"3.54.5"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Excess sedentary time (ST) is recognized as an important modifiable risk factor for coronary heart disease (CHD). However, whether the associations of genetic susceptibility with CHD incidence can be modified by replacing wearable\u2010device\u2010measured ST with physical activity (PA) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the associations of wearable\u2010device\u2010measured ST replaced by PA with incident CHD across strata of genetic susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 77,500 White British (57% female) with valid wrist\u2010worn accelerometry and without prevalent CHD\/stroke from UK Biobank. Genetic susceptibility to CHD was quantified through weighted polygenic risk scores for CHD based on 300 single\u2010nucleotide polymorphisms. Wrist\u2010worn accelerometer data were used to derive ST, light PA, and moderate\u2010to\u2010vigorous PA (MVPA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reallocation of 60\u00a0min\/day of ST into the same amount of MVPA was associated with approximately 9% lower relative risk of CHD for all participants and across strata of genetic risk: replacement of 1\u00a0min\/day of ST associated with &lt;1% lower relative risk of CHD. No evidence of interaction (<jats:italic>p<\/jats:italic>: 0.784) was found between genetic risk and ST for CHD risk. Reallocating 60\u00a0min\/day of ST into the same MVPA time was associated with greater absolute CHD risk reductions at high genetic risk (0.27%) versus low genetic risk (0.15%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Replacing any amount of ST with an equal amount of MVPA time is associated with a lower relative risk of CHD, irrespective of genetic susceptibility to CHD. Reductions in CHD absolute risk for replacing ST with MVPA are greater at high genetic risk versus low genetic risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13715","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T06:01:23Z","timestamp":1692856883000},"page":"38-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Replacing device\u2010measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk"],"prefix":"10.1111","volume":"295","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-7191","authenticated-orcid":false,"given":"Youngwon","family":"Kim","sequence":"first","affiliation":[{"name":"School of Public Health The University of Hong Kong Li Ka Shing Faculty of Medicine  Pokfulam Hong Kong"},{"name":"MRC Epidemiology Unit University of Cambridge School of Clinical Medicine  Cambridge United 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