{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:14:13Z","timestamp":1788430453949,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) affects extra\u2010respiratory systems, with small\u2010scale studies showing worsened male lower urinary tract symptoms (LUTS) after coronavirus disease 2019 (COVID\u201019). This study explores the correlation between SARS\u2010CoV\u20102 infection and male benign prostatic hyperplasia (BPH) complications using large\u2010scale real world data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>All male patients attending the public healthcare system in Hong Kong receiving alpha\u2010blocker monotherapy for LUTS from 2021 to 2022 were included in this study. Patients with and without positive polymerase chain reaction (PCR) test for SARS\u2010CoV\u20102 are selected as the exposure group and control group, respectively. Baseline characteristics are retrieved, with propensity score matching performed to ensure balance of covariates between the two groups. BPH complications were then compared and subgroup analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After propensity score matching, 17,986 patients were included for analysis, among which half had PCR\u2010confirmed SARS\u2010CoV\u20102 infection (<jats:italic>n<\/jats:italic>\u00a0=\u00a08993). When compared to controls, the SARS\u2010CoV\u20102 group demonstrated statistically significant higher incidence of retention of urine (4.55% vs. 0.86%,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), haematuria (1.36% vs. 0.41%,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), clinical urinary tract infection (UTI) (4.31% vs. 1.49%,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), culture\u2010proven bacteriuria (9.02% vs. 1.97%,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and addition of 5ARI (0.50% vs. 0.02%,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Subgroup analysis demonstrated similar differences across different age groups. There are no statistically significance differences in incidence of retention, haematuria, or addition of 5ARI across different COVID\u201019 severities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SARS\u2010CoV\u20102 infection is associated with increased incidence of urinary retention, haematuria, UTI and the addition of combination therapy in the short term, regardless of COVID\u201019 severity. This is the largest study demonstrating the detrimental urological effects of SARS\u2010CoV\u20102 infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13719","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:10:57Z","timestamp":1697613057000},"page":"775-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["SARS\u2010CoV\u20102 infection correlates with male benign prostatic hyperplasia deterioration"],"prefix":"10.1111","volume":"294","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-0472","authenticated-orcid":false,"given":"Alex Qinyang","family":"Liu","sequence":"first","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery The Chinese University of Hong Kong New Territories Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Ka\u2010Fung","family":"Chiu","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery The Chinese University of Hong Kong New Territories Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Chi\u2010Hang","family":"Yee","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery The Chinese University of Hong Kong New Territories Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Fai","family":"Ng","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery The Chinese University of Hong Kong New Territories Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy Yuen\u2010Chun","family":"Teoh","sequence":"additional","affiliation":[{"name":"S.H. 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