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This paper provides an overview of characteristics, risk factors, possible mechanisms, and management strategies for cognitive dysfunction in post\u2010COVID\u201019 condition (PCC).<\/jats:p>\n                  <jats:p>Prolonged cognitive dysfunction is one of the most common impairments in PCC, affecting between 17% and 28% of the individuals more than 12 weeks after the infection and persisting in some cases for several years. Cognitive dysfunctions can be manifested as a wide range of symptoms including memory impairment, attention deficit, executive dysfunction, and reduced processing speed. Risk factors for developing PCC, with or without cognitive impairments, include advanced age, preexisting medical conditions, and the severity of acute illness. The underlying mechanisms remain unclear, but proposed contributors include neuroinflammation, hypoxia, vascular damage, and latent virus reactivation not excluding the possibility of direct viral invasion of the central nervous system, illustrating complex viral pathology.<\/jats:p>\n                  <jats:p>As the individual variation of the cognitive impairments is large, a neuropsychological examination and a person\u2010centered multidimensional approach are required. According to the World Health Organization, limited evidence on COVID\u201019\u2010related cognitive impairments necessitates implementing rehabilitation interventions from established practices of similar conditions. Psychoeducation and compensatory skills training are recommended. Assistive products and environmental modifications adapted to individual needs might be helpful. In specific attention\u2010 and working memory dysfunctions, cognitive training\u2014carefully monitored for intensity\u2014might be effective for people who do not suffer from post\u2010exertional malaise. Further research is crucial for evidence\u2010based interventions specific to COVID\u201019\u2010related cognitive impairments.<\/jats:p>","DOI":"10.1111\/joim.13720","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T02:39:10Z","timestamp":1695868750000},"page":"563-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Cognitive dysfunction in post\u2010COVID\u201019 condition: Mechanisms, management, and rehabilitation"],"prefix":"10.1111","volume":"294","author":[{"given":"Marika","family":"M\u00f6ller","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Division of Rehabilitation Medicine Karolinska Institutet Danderyd University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Borg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Division of Rehabilitation Medicine Karolinska Institutet Danderyd University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Janson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences: Respiratory, Allergy and Sleep Research Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lerm","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Division of Inflammation and Infection Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Normark","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Niward","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, and Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6930e1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.18931"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01840-0"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13482"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.0750"},{"key":"e_1_2_12_7_1","unstructured":"World Health Organization.A clinical case definition of post COVID\u201019 condition by a Delphi consensus 6 October 2021.Geneva Switzerland:World Health Organization. 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