{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T17:13:55Z","timestamp":1782148435570,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100017726","name":"Fondazione Diabete Ricerca","doi-asserted-by":"publisher","award":["Grant SID\u2010Fondazione Diabete Ricerca 2020"],"award-info":[{"award-number":["Grant SID\u2010Fondazione Diabete Ricerca 2020"]}],"id":[{"id":"10.13039\/100017726","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015410","name":"Societ\u00e0 Italiana di Medicina Interna","doi-asserted-by":"publisher","award":["Grant di ricerca SIMI 2022"],"award-info":[{"award-number":["Grant di ricerca SIMI 2022"]}],"id":[{"id":"10.13039\/501100015410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An increased dietary fructose intake has been shown to exert several detrimental metabolic effects and contribute to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). An augmented intestinal abundance of the fructose carriers glucose transporter\u20105 (GLUT\u20105) and glucose transporter\u20102 (GLUT\u20102) has been found in subjects with obesity and type 2 diabetes. Herein, we investigated whether elevated intestinal levels of GLUT\u20105 and GLUT\u20102, resulting in a higher dietary fructose uptake, are associated with NAFLD and its severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>GLUT\u20105 and GLUT\u20102 protein levels were assessed on duodenal mucosa biopsies of 31 subjects divided into 2 groups based on ultrasound\u2010defined NAFLD presence who underwent an upper gastrointestinal endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with NAFLD exhibited increased duodenal GLUT\u20105 protein levels in comparison to those without NAFLD, independently of demographic and anthropometric confounders. Conversely, no difference in duodenal GLUT\u20102 abundance was observed amongst the two groups. Univariate correlation analyses showed that GLUT\u20105 protein levels were positively related with body mass index, waist circumference, fasting and 2\u00a0h post\u2010load insulin concentrations, and insulin resistance (IR) degree estimated by homeostatic model assessment of IR (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.44; <jats:italic>p\u00a0=<\/jats:italic>\u00a00.02) and liver IR (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.46; <jats:italic>p\u00a0=<\/jats:italic>\u00a00.03) indexes. Furthermore, a positive relationship was observed between duodenal GLUT\u20105 abundance and serum uric acid concentrations (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.40; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05), a product of fructose metabolism implicated in NAFLD progression. Importantly, duodenal levels of GLUT\u20105 were positively associated with liver fibrosis risk estimated by NAFLD fibrosis score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased duodenal GLUT\u20105 levels are associated with NAFLD and liver fibrosis. Inhibition of intestinal GLUT\u20105\u2010mediated fructose uptake may represent a strategy for prevention and treatment of NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13729","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:28:53Z","timestamp":1696613333000},"page":"171-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between higher duodenal levels of the fructose carrier glucose transporter\u20105 and nonalcoholic fatty liver disease and liver fibrosis"],"prefix":"10.1111","volume":"295","author":[{"given":"Francesca","family":"De Vito","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences University Magna Graecia of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Suraci","sequence":"additional","affiliation":[{"name":"Department of Health Sciences 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