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The vagus nerve inflammatory reflex is an important, well\u2010characterized mechanism for the reflexive suppression of cytokine storm, and its experimental or clinical impairment facilitates the onset and progression of hyperinflammation. Recent pathological evidence from COVID\u201019 victims reveals viral infection and inflammation in the vagus nerve and associated nuclei in the medulla oblongata. Although it has been suggested that vagus nerve inflammation in these patients mediates dysregulated respiration, whether it also contributes to dysfunction of the vagus nerve inflammatory reflex has not been addressed. Because lethality and tissue injury in acute COVID\u201019 are characterized by cytokine storm, it is plausible to consider evidence that impairment of the inflammatory reflex may contribute to overproduction of cytokines and resultant hyperinflammatory pathogenesis. Accordingly, here the authors discuss the inflammatory reflex, the consequences of its dysfunction in COVID\u201019, and whether there are opportunities for therapeutic intervention.<\/jats:p>","DOI":"10.1111\/joim.13746","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T11:53:08Z","timestamp":1701258788000},"page":"91-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Vagus nerve SARS\u2010CoV\u20102 infection and inflammatory reflex dysfunction: Is there a causal relationship?"],"prefix":"10.1111","volume":"295","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0316-3860","authenticated-orcid":false,"given":"Ulf","family":"Andersson","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin 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