{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T20:24:07Z","timestamp":1769804647859,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Effects of intensive blood pressure (BP) control on cognitive outcomes in patients with excess orthostatic BP changes are unclear. We aimed to evaluate whether orthostatic BP changes modified the effects of BP intervention on cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 8547 participants from the Systolic Blood Pressure Intervention Trial Memory and cognition IN Decreased Hypertension. Associations between orthostatic BP changes and incident cognitive outcomes were evaluated by restricted cubic spline curves based on Cox models. The interactions between orthostatic BP changes and intensive BP intervention were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The U\u2010shaped associations were observed between baseline orthostatic systolic BP changes and cognitive outcomes. However, there were insignificant interactions between either change in orthostatic systolic BP (P for interaction\u00a0=\u00a00.81) or diastolic BP (P for interaction\u00a0=\u00a00.32) and intensive BP intervention for the composite outcome of probable dementia or mild cognitive impairment (MCI). The hazard ratio of intensive versus standard target for the composite cognitive outcome was 0.82 (95% CI 0.50\u20131.35) in those with an orthostatic systolic BP reduction of &gt;20\u00a0mmHg and 0.41 (95% CI 0.21\u20130.80) in those with an orthostatic systolic BP increase of &gt;20\u00a0mmHg. Results were similar for probable dementia and MCI. The annual changes in global cerebral blood flow (P for interaction\u00a0=\u00a00.86) consistently favored intensive BP treatment across orthostatic systolic BP changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intensive BP control did not have a deteriorating effect on cognitive outcomes among hypertensive patients experiencing significant postural BP changes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13758","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T09:06:17Z","timestamp":1702976777000},"page":"557-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Orthostatic blood pressure changes do not influence cognitive outcomes following intensive blood pressure control"],"prefix":"10.1111","volume":"295","author":[{"given":"Chao","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manlin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine Peking Union Medical College and Chinese Academy of Medical Science  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwei","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songnan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ribo","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyong","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caihua","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"},{"name":"Heart Health Research Center  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzeng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"},{"name":"The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Neurology Royal Prince Alfred Hospital, University of Sydney  Sydney Australia"},{"name":"The George Institute for Global Health Faculty of Medicine University of New South Wales  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5387-5957","authenticated-orcid":false,"given":"Changsheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases  Chaoyang Beijing China"},{"name":"Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"},{"name":"Engineering Research Center of Medical Devices for Cardiovascular Diseases Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09048"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006027"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy418"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07334"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17454"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010420"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18571"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.927009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(20)30185-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.10575"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4249"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac584"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.18557"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21537"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14745"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21442"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774514537404"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14309"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15887"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21442"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/37.3.323"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.10551"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.0074"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008976"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S72316"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glq068"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317512466692"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb02576.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20-4298"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2022-321276"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13657"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26632"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022066"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14030"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01380.x"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T16:15:42Z","timestamp":1710432942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.13758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,18]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/joim.13758"],"URL":"https:\/\/doi.org\/10.1111\/joim.13758","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,18]]},"assertion":[{"value":"2023-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}