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Thus, it is desirable to review the platelet\u2013hyperlipidaemia interplay and its impact on atherogenesis. Native low\u2010density lipoprotein (nLDL) and oxidized LDL (oxLDL) are the key proatherosclerotic components of hyperlipidaemia. nLDL binds to the platelet\u2010specific LDL receptor (LDLR) ApoE\u2010R2\u2032, whereas oxLDL binds to the platelet\u2010expressed scavenger receptor CD36, lectin\u2010type oxidized LDLR 1 and scavenger receptor class A 1. Ligation of nLDL\/oxLDL induces mild platelet activation and may prime platelets for other platelet agonists. Platelets, in turn, can modulate lipoprotein metabolisms. Platelets contribute to LDL oxidation by enhancing the production of reactive oxygen species and LDLR degradation via proprotein convertase subtilisin\/kexin type 9 release. Platelet\u2010released platelet factor 4 and transforming growth factor \u03b2 modulate LDL uptake and foam cell formation. Thus, platelet dysfunction and hyperlipidaemia work in concert to aggravate atherogenesis. Hypolipidemic drugs modulate platelet function, whereas antiplatelet drugs influence lipid metabolism. The research prospects of the platelet\u2013hyperlipidaemia interplay in atherosclerosis are also discussed.<\/jats:p>","DOI":"10.1111\/joim.13794","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T11:33:11Z","timestamp":1714908791000},"page":"39-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Platelets as an inter\u2010player between hyperlipidaemia and atherosclerosis"],"prefix":"10.1111","volume":"296","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-7251","authenticated-orcid":false,"given":"Nailin","family":"Li","sequence":"first","affiliation":[{"name":"Karolinska Institutet Department of Medicine\u2010Solna Division of Cardiovascular Medicine  Stockholm 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