{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:50:01Z","timestamp":1791802201021,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009457","name":"Region Sj\u00e6lland","doi-asserted-by":"publisher","award":["R22A673"],"award-info":[{"award-number":["R22A673"]}],"id":[{"id":"10.13039\/501100009457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001448","name":"Alpha-1 Foundation","doi-asserted-by":"publisher","award":["612336"],"award-info":[{"award-number":["612336"]}],"id":[{"id":"10.13039\/100001448","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF19OC0058811"],"award-info":[{"award-number":["NNF19OC0058811"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n \u03b1\n 1<\/jats:sub>\n \u2010Antitrypsin deficiency is characterized by elevated elastase activity and excessive elastin degradation, which may impact cancer development and progression. We tested the hypothesis that individuals with \u03b1\n 1<\/jats:sub>\n \u2010antitrypsin deficiency have increased susceptibility to cancer in the Danish population.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In a nationwide nested study, we identified 2702 individuals with \u03b1\n 1<\/jats:sub>\n \u2010antitrypsin deficiency and 26,750 control subjects without \u03b1\n 1<\/jats:sub>\n \u2010antitrypsin deficiency matched on age, sex, and municipality. We recorded admissions due to cancer as outcomes during a median follow\u2010up of 62 years.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Individuals with \u03b1\n 1<\/jats:sub>\n \u2010antitrypsin deficiency versus control subjects had an increased hazard of skin cancer (2.18, 95%CI: 1.81\u20132.63), leukemia (1.76, 1.12\u20132.79), liver cancer (3.91, 2.23\u20136.85), and cancer overall (1.25, 1.13\u20131.38). Corresponding hazard ratios when the entire Danish population was used as control group were 3.02 (2.55\u20133.58), 1.83 (1.19\u20132.81), 4.46 (2.74\u20137.28), and 1.45 (1.31\u20131.59). When the analysis was stratified according to comorbidities, the hazard for skin cancer was higher in those with chronic obstructive pulmonary disease (COPD) (3.59, 2.60\u20134.95) and skin disease (2.93, 2.19\u20133.92) but remained elevated in those without any of these diseases. Hazards for skin cancer in individuals with \u03b1\n 1<\/jats:sub>\n \u2010antitrypsin deficiency were similar when stratified by liver cirrhosis and ischemic heart disease (\n p<\/jats:italic>\n s for interaction: \u22650.76). Hazards for liver cancer in individuals with \u03b1\n 1<\/jats:sub>\n \u2010antitrypsin deficiency versus control subjects were similar when stratified according to liver cirrhosis, COPD, skin disease, and ischemic heart disease (\n p<\/jats:italic>\n s for interaction: \u22650.13).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Individuals with \u03b1\n 1<\/jats:sub>\n \u2010antitrypsin deficiency have increased risks of skin cancer, leukemia, and liver cancer in the Danish population.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/joim.20016","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T11:23:09Z","timestamp":1727781789000},"page":"460-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Alpha\u20101 antitrypsin deficiency associated with increased risks of skin cancer, leukemia, and hepatic cancer: A nationwide cohort study"],"prefix":"10.1111","volume":"296","author":[{"given":"Nanna J.","family":"Korsb\u00e6k","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Zealand University Hospital K\u00f8ge Denmark"},{"name":"Department of Clinical Medicine Faculty of Health & Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eskild M.","family":"Landt","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Zealand University Hospital K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C. W.","family":"Marott","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Zealand University Hospital K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-7220","authenticated-orcid":false,"given":"B\u00f8rge G.","family":"Nordestgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health & Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Herlev Gentofte Hospital Herlev Denmark"},{"name":"Copenhagen General Population Study Copenhagen University Hospital Herlev Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle R.","family":"Vinding","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health & Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Dermatology Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor B. E.","family":"Jemec","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health & Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Dermatology Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Zealand University Hospital K\u00f8ge Denmark"},{"name":"Department of Clinical Medicine Faculty of Health & Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Copenhagen General Population Study Copenhagen University Hospital Herlev Gentofte Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1910234"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.51"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2022.03.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2023.107222"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101799"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01414-7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03200-2021"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2020.100914"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000153720"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.11.1213"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2000.3089"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-23-0414"},{"key":"e_1_2_11_14_1","first-page":"885","article-title":"Complete inhibition of spontaneous pulmonary metastasis of human lung carcinoma cell line EBC\u20101 by a neutrophil elastase inhibitor (ONO\u20105046.Na)","volume":"18","author":"Inada M","year":"1998","journal-title":"Anticancer Res."},{"key":"e_1_2_11_15_1","first-page":"103","article-title":"Neutrophil elastase inhibitor (ONO\u20105046.Na) suppresses the proliferation, motility and chemotaxis of a pancreatic carcinoma cell line, Capan\u20101","volume":"98","author":"Kamohara H","year":"1997","journal-title":"Res Commun Mol Pathol Pharmacol."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3374"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00319-2023"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-01973-3"},{"key":"e_1_2_11_19_1","unstructured":"Local government Denmark Weidekampsgade 10 DK\u20102300 Copenhagen S:https:\/\/www.kl.dk\/om\u2010kl\/english\/municipal\u2010responsibilities. 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