{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:03:28Z","timestamp":1792029808432,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2023\u201001807"],"award-info":[{"award-number":["2023\u201001807"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although glomerular diseases are the third most frequent cause of end\u2010stage kidney disease worldwide, little is known about their long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In patients with chronic kidney disease (CKD) stage 3\u20135 enrolled in the Swedish Renal Registry, we compared risks of hospitalization, kidney replacement therapy (KRT), major cardiovascular events (MACE), and death of the four most frequent primary glomerular diseases (IgA nephropathy [IgAN], focal segmental glomerulosclerosis [FSGS], minimal change disease [MCD], and membranous nephropathy [MN]), and patients with CKD due to the most common non\u2010communicable diseases (control\u2010CKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 2396 patients with glomerular disease (97% biopsy\u2010proven, 69% men, 57 years, eGFR 29\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      , uACR 88\u00a0mg\/mmol, 1524 with IgAN, 398 FSGS, 94 MCD, and 380 MN) and 37,697 controls (64% men, 74 years, eGFR 25\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      , uACR 23\u00a0mg\/mmol), mainly with diabetic nephropathy and nephroangiosclerosis. The median follow\u2010up was 6.3 (3.3; 9.9) years. Compared with control\u2010CKD, patients with primary glomerular diseases generally had a lower risk of hospitalization, MACE (adjusted hazard ratios [HRs] ranging from 0.44 to 0.88 depending on the etiology) and death (HRs ranging 0.45\u20130.76). Patients with IgAN and FSGS had a faster eGFR decline and a higher rate of KRT (HRs 1.26 [95%CI: 1.15\u20131.37] and 1.34 [1.15\u20131.57], respectively). Conversely, patients with MN and MCD had a lower KRT rate and slower eGFR decline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite having a lower relative risk of hospitalization, cardiovascular events and mortality, patients with IgAN and FSGS are at higher risk of CKD progression than the most common etiologies of CKD, emphasizing the need for more stringent treatment strategies in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.20024","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T20:59:58Z","timestamp":1731531598000},"page":"22-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Primary glomerular diseases and long\u2010term adverse health outcomes: A nationwide cohort study"],"prefix":"10.1111","volume":"297","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6716-1157","authenticated-orcid":false,"given":"Anne\u2010Laure","family":"Faucon","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Epidemiology INSERM UMR 1018, Centre for Epidemiology and Population Health, Paris\u2010Saclay University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Lando","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Biostatistics, University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charikleia","family":"Chrysostomou","sequence":"additional","affiliation":[{"name":"Department of Nephrology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Clinical Science Intervention and Technology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6183-5878","authenticated-orcid":false,"given":"Julia","family":"Wijkstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Nephrology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Clinical Science Intervention and Technology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Department of Medical Specialist Care Nephrology Clinic Danderyd University Hospital  Stockholm Sweden"},{"name":"Department of Clinical Sciences Karolinska Institutet Danderyd Hospital  Stockholm Sweden"},{"name":"MedTechLabs BioClinicum Karolinska University Hospital  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rino","family":"Bellocco","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Biostatistics, University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e5rten","family":"Segelmark","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University  Lund Sweden"},{"name":"Department of Nephrology Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Nephrology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Clinical Science Intervention and Technology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4763-2024","authenticated-orcid":false,"given":"Juan\u2010Jes\u00fas","family":"Carrero","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Medical Specialist Care Nephrology Clinic Danderyd University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Anon.2022 Annual data report\u2014US Renal Data System USRDS. 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