{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:32:34Z","timestamp":1789997554696,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T00:00:00Z","timestamp":1734825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T00:00:00Z","timestamp":1734825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High\u2010intensity statin therapy significantly reduces mortality and cardiovascular events in patients with atherosclerotic cardiovascular disease (ASCVD). However, moderate\u2010intensity statins are often preferred for elderly patients due to their higher risk of intolerance to high\u2010intensity statins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the incidence of statin\u2010associated muscle symptoms (SAMS) and the effect on low\u2010density lipoprotein cholesterol (LDL\u2010C) levels between elderly ASCVD patients receiving high\u2010intensity statin monotherapy and those receiving moderate\u2010intensity statin with ezetimibe in a combination therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>In a prospective, multicenter, open\u2010label trial conducted in South Korea, 561 patients aged 70 years or above with ASCVD were randomly assigned to receive either moderate\u2010intensity statin with ezetimibe combination therapy (rosuvastatin 5\u00a0mg with ezetimibe 10\u00a0mg) or high\u2010intensity statin monotherapy (rosuvastatin 20\u00a0mg) over 6 months. The primary endpoint was the incidence of SAMS, and the key secondary endpoint was the achievement of target LDL\u2010C levels (&lt;70\u00a0mg\/dL) within 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The primary endpoint showed a lower incidence of SAMS in the combination therapy group (0.7%) compared to the high\u2010intensity statin monotherapy group (5.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005). Both groups achieved similar LDL\u2010C levels, with 75.4% in the combination therapy group and 68.7% in the monotherapy group reaching target levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Moderate\u2010intensity statin with ezetimibe combination therapy offers a lower risk of SAMS and similar LDL\u2010C reduction in elderly patients with ASCVD, compared to high\u2010intensity statin monotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.20029","type":"journal-article","created":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T11:08:54Z","timestamp":1734865734000},"page":"400-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Safety and efficacy of moderate\u2010intensity statin with ezetimibe in elderly patients with atherosclerotic cardiovascular disease"],"prefix":"10.1111","volume":"297","author":[{"given":"Jung\u2010Joon","family":"Cha","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Korea University Anam Hospital Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Korea University Anam Hospital Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-6678","authenticated-orcid":false,"given":"Soon Jun","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Korea University Anam Hospital Korea University College of Medicine  Seoul South 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Cardiology Department of Internal Medicine Korea University Anam Hospital Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pil Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Whan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Whan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Youn","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Cardiology CHA Bundang Medical Center CHA University  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Suk","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Incheon Sejong Hospital  Incheon South 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