{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:41:53Z","timestamp":1793166113298,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Research on Mesoamerican Nephropathy, chronic kidney disease of unknown cause and chronic kidney disease of nontraditional cause has been going on for more than 20 years. Thousands of manual workers, especially in agriculture, are affected. The disease has been reported in different countries and regions, not only from heat\u2010stressed sugarcane cutters in Central America but also from other occupational groups with strenuous work in hot environments. The cause of this disease is still debated. A multitude of causative factors have been suggested, including agrochemicals, water quality, infections, and heavy metals. The evidence that heat stress is the major cause of kidney disease is convincing, whereas the support for alternative causes is weak. Associations between exposure and kidney damage are strong, consistent, and specific, occur after acute and chronic exposure, display dose\u2010effect and dose\u2013response relationships, are plausible, and coherent. Improving working conditions by providing hydration, rest, and shade to heat\u2010stress\u2010exposed workers is beneficial. Continued global warming will increase the number of people at risk for dangerous heat exposure and kidney disease.<\/jats:p>","DOI":"10.1111\/joim.20037","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T10:19:58Z","timestamp":1732789198000},"page":"101-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Heat\u2010induced kidney disease: Understanding the impact"],"prefix":"10.1111","volume":"297","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5114-347X","authenticated-orcid":false,"given":"Carl\u2010Gustaf","family":"Elinder","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Technology, Department of Renal Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.26633\/RPSP.2020.15"},{"key":"e_1_2_13_3_1","first-page":"234","article-title":"Chronic interstitial nephritis in agricultural communities: a worldwide epidemic with social, occupational and environmental determinants","volume":"32","author":"Jayasumana C","year":"2017","journal-title":"Nephrol Dial Transplant."},{"key":"e_1_2_13_4_1","unstructured":"WesselingC CroweJ HogstedtC JakobssonK LucasR WegmanD.Report from the First International Research Workshop on MeN.Costa Rica:Program on Work Environment and Health in Central America (SALTRA) and Central American Institute for Studies on Toxic Substances (IRET) Universidad Nacional (UNA);2013."},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591576505800503"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12992-023-00981-2"},{"key":"e_1_2_13_7_1","volume-title":"Merchants of doubt: how a handful of scientists obscured the truth on issues from tobacco smoke to global warming","author":"Oreskes N","year":"2010"},{"key":"e_1_2_13_8_1","volume-title":"The cigarette century: the rise, fall, and deadly persistence of the product that defined America","author":"Brandt AM","year":"2007"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.7312\/mann15254"},{"key":"e_1_2_13_10_1","volume-title":"Occupational heat exposure and kidney disease","author":"Hansson E","year":"2022"},{"key":"e_1_2_13_11_1","unstructured":"ElinderC\u2010G.Commented summary report on available and published reports on Mesoamerican Nephropathy (MeN) Chronic Kidney Disease of unknown Cause (CKDu) CKDnT and CINAC.2024[cited 2024 October 17]. 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