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Here, we investigate whether plasma levels of the novel biomarker brain\u2010derived tau (BD\u2010tau) reflect cerebral infarct volumes and whether BD\u2010tau can improve clinical outcome prediction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The present study included 713 consecutive cases from two different hospital\u2010based cohorts,\n                      <jats:italic>the<\/jats:italic>\n                      <jats:italic>Sahlgrenska Academy Study on Ischemic Stroke<\/jats:italic>\n                      (\n                      <jats:italic>SAHLSIS<\/jats:italic>\n                      ) and\n                      <jats:italic>SAHLSIS phase 2<\/jats:italic>\n                      (\n                      <jats:italic>SAHLSIS2<\/jats:italic>\n                      ). Acute stroke severity was determined by the Scandinavian Stroke Scale converted to the National Institutes of Health stroke scale (NIHSS) in\n                      <jats:italic>SAHLSIS<\/jats:italic>\n                      and by the NIHSS in\n                      <jats:italic>SAHLSIS2<\/jats:italic>\n                      . All participants were assessed for functional outcome 3 months after stroke by the modified Rankin Scale, and 254 participants in\n                      <jats:italic>SAHLSIS<\/jats:italic>\n                      had quantitative neuroimaging available.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Plasma BD\u2010tau concentrations and cerebral infarct volumes were highly correlated (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      0.72,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). BD\u2010tau improved the prognostic accuracy of suffering an unfavorable outcome over age and stroke severity in the whole cohort. However, the gain in predictive power was dependent on stroke severity and infarct location. The largest improvement was observed for mild ischemic strokes (NIHSS &lt;5; area under the curve [AUC]\u00a0=\u00a00.73 for age\u00a0+\u00a0NIHSS versus AUC\u00a0=\u00a00.84 with addition of BD\u2010tau; DeLong\n                      <jats:italic>p<\/jats:italic>\n                      0.02), posterior circulation stroke (AUC\u00a0=\u00a00.75 vs. AUC\u00a0=\u00a00.84; DeLong\n                      <jats:italic>p<\/jats:italic>\n                      0.06) and more specifically for infarcts in the brainstem\/cerebellum (AUC\u00a0=\u00a00.74 vs. 0.87; DeLong\n                      <jats:italic>p<\/jats:italic>\n                      0.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Plasma BD\u2010tau can provide information on the extent of acute neuronal damage in ischemic stroke and adds prognostic value for outcome, especially for mild and posterior circulation strokes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.20041","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T02:08:54Z","timestamp":1733450934000},"page":"173-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Plasma brain\u2010derived tau correlates with cerebral infarct volume"],"prefix":"10.1111","volume":"297","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7897-9456","authenticated-orcid":false,"given":"Fernando","family":"Gonzalez\u2010Ortiz","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy, University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Region V\u00e4stra G\u00f6taland, Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  M\u00f6lndal 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