{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:27:29Z","timestamp":1785007649329,"version":"3.55.0"},"reference-count":70,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Paget's disease of the bone (PDB) is a metabolic bone disorder involving one or more skeletal sites. Cardiovascular diseases (CVDs) have been described in patients with PDB but have not been systematically analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to compare standard and advanced (speckle\u2010tracking) echocardiographic parameters measured in patients with PDB and controls matched for age, weight, height and history of hypertension but without metabolic bone disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicentre case\u2013control study included all patients with PDB referred to the Federico II and Siena Universities, Italy, from March 2019 to October 2022. During the same time, we enrolled at least one control for each patient, matched for age, sex, body mass index (BMI) and history of hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010nine patients with PDB and 115 healthy controls were enrolled in this study. All patients with PDB were treated with zoledronic acid at the time of diagnosis. Compared with controls, on standard echocardiography, patients with PDB showed a high prevalence of aortic and mitral valve calcifications and\/or sclerosis, reduced left ventricular (LV) ejection fraction, stroke volume, cardiac output, increased interventricular septum thickness, posterior wall thickness, LV mass index, relative wall thickness, relative diastolic wall thickness, <jats:italic>E<\/jats:italic>\/<jats:italic>e<\/jats:italic>\u2032 ratio and systemic vascular resistance. Using speckle\u2010tracking echocardiography, patients with PDB showed a lower global longitudinal strain and global myocardial work efficiency than controls. There was no relationship between the PDB activity and extent and severity of cardiac abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, the myocardial function and structure were impaired in patients with PDB. Additionally, PDB was associated with early subclinical myocardial damage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.20069","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T07:33:04Z","timestamp":1746689584000},"page":"630-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Standard and advanced echocardiographic study of patients with Paget's disease of bone: Evidence of a pagetic heart disease?"],"prefix":"10.1111","volume":"297","author":[{"given":"Alfonso","family":"Giaquinto","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Abate","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Vergatti","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Muscariello","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelaide","family":"Iervolino","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Pucci","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Cavati","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Pirrotta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpaolo","family":"De Filippo","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Robert\u2010Debr\u00e9 Service d'Endocrinologie\u2010Diab\u00e9tologie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0051-7152","authenticated-orcid":false,"given":"Roberta","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanfranco","family":"D'Elia","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Merlotti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6833-4232","authenticated-orcid":false,"given":"Luigi","family":"Gennari","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neurosciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0331-0392","authenticated-orcid":false,"given":"Domenico","family":"Rendina","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-008-8208-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.3.465"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.04.024"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-019-00522-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1204713"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3657"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.932065"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4090"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.52011"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.244707"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900419"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906103402306"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9689106"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13668-019-00286-0"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-019-05098-0"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2018.7649"},{"issue":"3","key":"e_1_2_11_19_1","first-page":"249","article-title":"Heart failure and bone blood flow in osteitis deformans","volume":"5","author":"Edholm OG","year":"1945","journal-title":"Clin Sci."},{"issue":"3","key":"e_1_2_11_20_1","first-page":"271","article-title":"Cardiac output in osteitis deformans","volume":"12","author":"Howarth S","year":"1953","journal-title":"Clin Sci."},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1979.tb04165.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(84)90085-8"},{"issue":"1","key":"e_1_2_11_23_1","first-page":"31","article-title":"Assessment of cardiac function by echocardiography in Paget's disease of bone","volume":"18","author":"Morales\u2010Piga AA","year":"2000","journal-title":"Clin Exp Rheumatol."},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00946.2004"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2011.30.1.71"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-5-27"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12071697"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31179-X"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000932"},{"issue":"18","key":"e_1_2_11_30_1","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA Guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich PA","year":"2022","journal-title":"Circulation."},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm342"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz009"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjmed-2022-000308"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S002"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-020-01331-z"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn548"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.101"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03344156"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-024-02318-1"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.31"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex244"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey108"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000906"},{"issue":"12","key":"e_1_2_11_49_1","first-page":"1390","article-title":"Normal reference values of multilayer longitudinal strain according to age decades in a healthy population: a single\u2010centre experience","volume":"19","author":"Alcidi GM","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging."},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194521"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.03.006"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00576.2023"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.12.037"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.08.005"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2014.05.003"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-021-00811-w"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14122369"},{"key":"e_1_2_11_58_1","unstructured":"Agenzia Italiana del Farmaco (AIFA).https:\/\/www.aifa.gov.it\/documents\/20142\/1728113\/nota\u201096\u2010all\u20101.pdf."},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-003-0011-y"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2018.12.007"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy010"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-023-09812-6"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13494"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-014-0060-5"},{"issue":"24","key":"e_1_2_11_65_1","first-page":"8822","article-title":"Serum sclerostin as a potential novel biomarker for heart valve calcification in patients with chronic kidney disease","volume":"22","author":"Ji YQ","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci."},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.11.011"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.07.012"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-011-9549-2"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-1894-0"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.11005\/jbm.2014.21.2.85"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2910"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.20069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T16:50:02Z","timestamp":1747673402000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.20069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":70,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/joim.20069"],"URL":"https:\/\/doi.org\/10.1111\/joim.20069","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]},"assertion":[{"value":"2025-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}