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Cross\u2010sectional analyses of self\u2010reported variables were conducted using multivariable logistic and linear regression models. Cox proportional\u2010hazard models were used to assess risks for incident outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 323,640 participants (60.3% were female, mean age: 51.3 years), 20.7%, 11.0%, and 9.5% were with Classes I, II, and III obesity, respectively. Higher BMI categories were correlated with worse health metrics, with Class III obesity exhibiting the greatest disparities. Among those with Class III obesity, 9.6% (vs. 3.2% for normal weight) reported poor overall health, 28.3% (vs. 13.2%) reported severe pain, and 11.8% (vs. 8.4%) had prevalent insomnia. Graded associations were observed across high BMI categories, with Class III obesity showing the strongest effects. Compared with normal weight, in Class III obesity, the odds ratio (95% CI) was 3.82 (3.69\u20133.96) for fair\/poor overall health, 3.93 (3.71\u20134.17) for severe pain, and 3.13 (2.98\u20133.29) for severely limited physical activity; the hazard ratio (95% CI) was 2.83 (2.36\u20133.40) for fibromyalgia and 1.53 (1.41\u20131.65) for insomnia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Obesity imposes a substantial burden on broad aspects of well\u2010being in the US population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.20083","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:15:04Z","timestamp":1746497704000},"page":"657-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Adverse effects of obesity on overall health, quality of life, and 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