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The primary outcome was MOF, and the secondary outcome was treatment with osteoporosis medications. Marginal Cox models were used to compare time\u2010to\u2010event outcomes. The study period spanned from 1 July 2005 until 31 December 2020. Individuals at risk were followed from inclusion until censored or the end of the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 77 patients with AAD (7.1\/1000 person\u2010years [PY]), and 387 matched controls (3.9\/1000 PY) were diagnosed with MOF. The risk of MOF was higher in patients with AAD compared to matched controls, with an adjusted hazard ratio (aHR) of 1.82 (95% confidence interval [CI], 1.41\u20132.35) and increased in both male and female patients, with aHR of 2.51 (95% CI, 1.56\u20134.02) and 1.65 (95% CI, 1.22\u20132.24), respectively. Patients with AAD had an increased risk of treatment with osteoporosis medications: aHR 3.25 (95% CI, 2.71\u20133.99), compared to controls. No significant differences in MOF rates were observed between patients treated with intermediate or high doses of glucocorticoids compared to low doses (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.967 and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.580, respectively). Similarly, stratification by mineralocorticoid dose (&lt;0.10 vs. \u22650.10\u00a0mg\/day) showed no significant association regarding MOF (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.915).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The risk of MOF is increased in patients with AAD without any apparent correlation to adrenal hormone replacement doses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.20085","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T02:43:18Z","timestamp":1743993798000},"page":"518-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased risk of osteoporotic fractures and osteoporosis in patients with Addison's disease in Sweden: A nationwide population\u2010based cohort study"],"prefix":"10.1111","volume":"297","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-3287","authenticated-orcid":false,"given":"Stavros","family":"Stergianos","sequence":"first","affiliation":[{"name":"Department of Endocrinology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Spelman","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5473-3312","authenticated-orcid":false,"given":"Daniel","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Medicine (Solna) Center for Molecular Medicine Karolinska Institutet  Sweden"},{"name":"Department of Immunology, Genetics and Pathology 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