{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:05:11Z","timestamp":1791173111345,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colchicine shows promise in reducing cardiovascular risk, but a recent study raised the question whether this is really the case. We conducted a meta\u2010analysis of randomized controlled trials (RCTs) to assess its impact on cardiovascular outcomes in secondary prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched major databases up to March 2025 for RCTs comparing colchicine to placebo over a treatment duration of \u226512 months, reporting major adverse cardiovascular events (MACEs). Both fixed\u2010 and random\u2010effects models were used to compute pooled risk ratios (RRs) and 95% confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six RCTs comprising 21,774 patients were included. Colchicine significantly reduced the risk of MACEs (RR 0.74 [0.60\u20130.92]) and specific components of primary outcome (myocardial infarction, RR 0.85 [0.73\u20130.98]; stroke, RR 0.79 [0.65\u20130.95]), with no significant effect on cardiac death and revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results support the efficacy of low\u2010dose colchicine in reducing MACEs when added to standard care for at least 12 months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.20107","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T08:50:43Z","timestamp":1751878243000},"page":"711-717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Colchicine and cardiovascular events: An updated meta\u2010analysis of published randomized controlled trials"],"prefix":"10.1111","volume":"298","author":[{"given":"Sining","family":"Xie","sequence":"first","affiliation":[{"name":"Epidemiology and Preventive Pharmacology Service (SEFAP) Department of Pharmacological and Biomolecular Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Galimberti","sequence":"additional","affiliation":[{"name":"IRCCS MultiMedica  Sesto San Giovanni (MI) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Olmastroni","sequence":"additional","affiliation":[{"name":"Epidemiology and Preventive Pharmacology Service (SEFAP) Department of Pharmacological and Biomolecular Sciences University of Milan  Milan Italy"},{"name":"IRCCS MultiMedica  Sesto San Giovanni (MI) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberico L.","family":"Catapano","sequence":"additional","affiliation":[{"name":"Epidemiology and Preventive Pharmacology Service (SEFAP) Department of Pharmacological and Biomolecular Sciences University of Milan  Milan Italy"},{"name":"IRCCS MultiMedica  Sesto San Giovanni (MI) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Casula","sequence":"additional","affiliation":[{"name":"Epidemiology and Preventive Pharmacology Service (SEFAP) Department of Pharmacological and Biomolecular Sciences University of Milan  Milan Italy"},{"name":"IRCCS MultiMedica  Sesto San Giovanni (MI) 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