{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T06:22:45Z","timestamp":1788070965203,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Type 2 diabetes mellitus (T2DM) and gout are associated with an increased risk of cardiovascular events. Despite the approval for the secondary prevention of cardiovascular diseases by the United States Food and Drug Administration in 2023, evidence regarding the effectiveness of colchicine among T2DM population remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to evaluate the association between the use of colchicine and the risk of major adverse cardiovascular events (MACE) among patients with gout and T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nationwide, population\u2010based cohort study with active comparator, new\u2010user design using nationwide claims data of South Korea (2010\u20132022). Patients with T2DM and gout who initiated colchicine or non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) from 2011 to 2022 were included. The primary outcome was MACE (myocardial infarction, ischemic stroke, and cardiovascular death). Secondary outcomes were each individual components of primary outcome and hospitalization due to heart failure. As\u2010treated approach with 30\u2010day grace period was applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Before propensity score (PS) matching, 13,019 colchicine users and 111,594 NSAIDs users were included in the study cohort (mean age, 65.5 vs. 62.9; 35.0% vs. 29.8% female). After 1:2 PS matching, 12,908 colchicine users and 25,816 NSAIDs users remained (mean age, 65.7 vs. 65.7 years; 35.2% vs. 35.1% female). The PS\u2010matched hazard ratio for MACE was 0.94 (95% confidence interval 0.65\u20131.36), and all secondary outcomes also resulted in null findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Use of colchicine does not significantly reduce the risk of MACE compared with NSAIDs in a real\u2010world population with T2DM and gout in South Korea between 2011 and 2022.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.70012","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T08:46:26Z","timestamp":1755938786000},"page":"604-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Colchicine and the risk of major adverse cardiovascular events in patients with gout and Type 2 diabetes: A nationwide cohort study"],"prefix":"10.1111","volume":"298","author":[{"given":"Minjeong","family":"Jeon","sequence":"first","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-7881","authenticated-orcid":false,"given":"Yongtai","family":"Cho","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungho","family":"Bea","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"},{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonkyoung","family":"You","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Kweon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Ajou University School of Medicine  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungho","family":"Ryu","sequence":"additional","affiliation":[{"name":"Center for Cohort Studies, Total Healthcare Center Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul South Korea"},{"name":"Department of Occupational and Environmental Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6945-9050","authenticated-orcid":false,"given":"Yoosoo","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Cohort Studies, Total Healthcare Center Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul South Korea"},{"name":"Department of Occupational and Environmental Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-7525","authenticated-orcid":false,"given":"Ju\u2010Young","family":"Shin","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon South Korea"},{"name":"Department of Biohealth Regulatory Science Sungkyunkwan University  Suwon South Korea"},{"name":"Samsung Advanced Institute for Health Sciences &amp; Technology Sungkyunkwan University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2021.05.013"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0441-1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2015-133691"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.190487"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.07.006"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38918"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154766"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1427-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-019-1107-y"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4078\/jrd.2023.0029"},{"key":"e_1_2_12_12_1","unstructured":"Agepha Pharma. 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