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These interactions are vital for maintaining physiological homeostasis and are mediated by hormones, cytokines, and metabolites. The kidney's role in these networks is pivotal, as dysfunction can exacerbate systemic diseases, highlighting the need for integrated therapeutic strategies. Chronic kidney disease and acute kidney injury serve as key examples of how kidney dysfunction impacts other organs, leading to complex disease states. The central idea is that the kidney functions within a network of physiological processes, influencing and being influenced by other organs. This review provides an overview of the mechanisms underlying kidney\u2010related inter\u2010organ communication, emphasizing the significance of these interactions in disease progression. We explore how advanced computational models and multi\u2010omics approaches can enhance our understanding of these complex networks, paving the way for precision medicine. The insights derived from this work underscore the potential for future research in developing innovative treatments that target these intricate pathways. By fostering interdisciplinary collaboration and leveraging emerging technologies, we aim to address the multifaceted nature of systemic diseases, offering new avenues for therapeutic intervention. This review represents a paradigm shift from reductionist to integrative approaches, emphasizing the importance of systemic balance and adaptation in human health, and sets the stage for future exploration into the interconnectedness of body systems.<\/jats:p>","DOI":"10.1111\/joim.70015","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T10:12:17Z","timestamp":1755857537000},"page":"368-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Inter\u2010organ crosstalk: The kidney's role in systemic health and disease"],"prefix":"10.1111","volume":"298","author":[{"given":"Carmine","family":"Zoccali","sequence":"first","affiliation":[{"name":"Renal Research Institute  New York New York USA"},{"name":"Institute of Molecular Biology and Genetics (Biogem)  Ariano Irpino Italy"},{"name":"Associazione Ipertensione, Nefrologia Trapianto (IPNET), c\/o Nefrologia, Grande Ospedale Metropolitano  Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Richard L. 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