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Treatments include psychosocial, behavioral, and pharmacological interventions. However, available pharmacological treatments remain limited, primarily targeting alcohol, tobacco, and opioid use disorders, with a lack of approved pharmacotherapies for other substance use disorders. This gap highlights a critical need to develop novel treatment options. Emerging evidence suggests that bidirectional brain\u2010periphery communications play important roles in the pathophysiology and progression of ASUDs. Gut\u2013brain hormones that are involved in the regulation of feeding and metabolism have been shown to influence reinforcing properties of food, alcohol, and other addictive substances. Additionally, stress\u2010related pathways, especially the hypothalamic\u2013pituitary\u2013adrenal axis, play a significant role in regulating behaviors that are related to ASUDs. Accordingly, feeding\u2010 and stress\u2010related neuroendocrine pathways represent novel pharmacotherapeutic targets for ASUDs. This narrative review discusses preclinical and clinical evidence for emerging pharmacotherapies that target ASUD\u2010related neuroendocrine systems. Special emphasis is placed on recent work with glucagon\u2010like peptide\u20101, ghrelin, fibroblast growth factor\u201021, amylin, glucocorticoids, and mineralocorticoids.<\/jats:p>","DOI":"10.1111\/joim.70021","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T09:14:21Z","timestamp":1758618861000},"page":"392-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neuroendocrinology meets addiction: Emerging pharmacotherapies on the horizon"],"prefix":"10.1111","volume":"298","author":[{"given":"Anna","family":"Loften","sequence":"first","affiliation":[{"name":"Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section Translational Addiction Medicine Branch National Institute on Drug Abuse Intramural Research Program, and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research National Institutes of Health  Baltimore 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