{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:49Z","timestamp":1787015629570,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary sclerosing cholangitis (PSC) is often intertwined with inflammatory bowel disease (IBD), presenting a complex clinical scenario. The coexistence of IBD\u2013PSC complicates disease management and progression, potentially exacerbating outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to evaluate the specific impact of IBD in patients with PSC, focusing on both liver\u2010related and IBD\u2010specific clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study, utilizing the TriNetX database, performed propensity score matching to compare clinical outcomes between IBD\u2013PSC and PSC\u2010only patients, as well as IBD\u2013PSC and IBD\u2010only patients. Diagnoses were identified based on International Classification of Diseases\u201010 coding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study analyzed 1941 patients with IBD\u2013PSC, 234,081 with IBD alone, and 628 with PSC alone. Patients with IBD\u2013PSC had significantly higher mortality compared to IBD alone (16.0% vs. 7.5%; hazard ratio [HR]: 2.256, 95% confidence interval [CI]: 1.853\u20132.747,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), as well as increased rates of hospitalization (32.8% vs. 14.5%; HR: 2.641, 95% CI: 2.213\u20133.152,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and intensive care unit admission (18.7% vs. 5.8%; HR: 3.691, 95% CI: 2.954\u20134.612,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Colorectal cancer was also more frequent in the IBD\u2013PSC group (2.4% vs. 0.7%; HR: 3.370, 95% CI: 1.846\u20136.152,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). When compared to PSC alone, IBD\u2013PSC patients had a higher rate of liver transplantation (12.3% vs. 8.0%; HR: 1.492, 95% CI: 1.012\u20132.198,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.042), whereas rates of hepatocellular carcinoma and cholangiocarcinoma were similar between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with coexisting IBD and PSC experience greater clinical severity, including higher mortality, hospitalization, and colorectal cancer risk. They also have increased liver transplant incidence. Further research is needed to explore underlying mechanisms and improve management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.70026","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T06:34:12Z","timestamp":1760510052000},"page":"626-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Coexisting inflammatory bowel disease in primary sclerosing cholangitis is associated with higher colorectal cancer and transplant risk"],"prefix":"10.1111","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5610-5897","authenticated-orcid":false,"given":"Chengu","family":"Niu","sequence":"first","affiliation":[{"name":"Internal Medicine Residency Program Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rainier Springs Behavioral Health Hospital  Vancouver Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajjwol","family":"Bhatta","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency Program Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency Program Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagesh","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency Program Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick I.","family":"Okolo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebubekir","family":"Daglilar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Charleston Area Medical Center\/CAMC Institute For Academic Medicine Program  Charleston West Virginia 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