{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:55Z","timestamp":1787015635545,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) mainly affects women of reproductive age. Late\u2010onset SLE patients (lo\u2010SLE, \u226550 years) are generally indolent and have less severe manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study aims to decode molecular differences underlying the distinct clinical presentations between lo\u2010SLE and early onset SLE patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a cohort of 243 treatment\u2010na\u00efve Chinese SLE female patients, we carried out clinical analysis and experimental validation studies. RNA\u2010seq was used to identify differentially expressed genes (DEGs) of lo\u2010SLE patients. Reverse transcription quantitative polymerase chain reaction and flow cytometry were utilized to validate DEGs and enriched cell types. The discovery was further compared to findings in a European cohort. The immunosuppressive function of CD71\n                      <jats:sup>+<\/jats:sup>\n                      CD235a\n                      <jats:sup>+<\/jats:sup>\n                      erythroid cells (CECs) was evaluated by coculturing peripheral blood mononuclear cells (PBMCs) with CECs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Differential expression analysis identified a group of hub upregulated genes in lo\u2010SLE patients. These genes, overrepresented in erythrocyte differentiation, are highly enriched in CECs. In our Chinese cohort, CECs abundance in peripheral blood was inversely correlated with disease activity. Increased CECs in treatment\u2010na\u00efve lo\u2010SLE patients may play an immunosuppressive role by inhibiting CD8\u207a T cell function and IFN\u2010\u03b3 production. This immunosuppressive role was evidenced by the significant suppression of IL\u20106, IFN\u2010\u03b3, and IL\u201017A production by healthy donor's PBMCs cocultured with SLE bone marrow\u2010derived CECs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This pioneering study has revealed a panel of CECs genes as potential molecular markers for lo\u2010SLE, supporting a novel erythroid modulation theory. These novel findings provide valuable insights into previously unrecognized molecular mechanisms underlying the latent disease activity of lo\u2010SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.70027","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T04:50:18Z","timestamp":1759812618000},"page":"637-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CD71\n                    <sup>+<\/sup>\n                    erythroid cell expansion in late\u2010onset systemic lupus erythematosus"],"prefix":"10.1111","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4824-2151","authenticated-orcid":false,"given":"Jian","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital, Tianjin Clinical Research Center for Rheumatic and Immune Diseases  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechen","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Department of Bioinformatics The Province and Ministry Cosponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), State Key Laboratory of Experimental Hematology, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital, Tianjin Clinical Research Center for Rheumatic and Immune Diseases  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Department of Bioinformatics The Province and Ministry Cosponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), State Key Laboratory of Experimental Hematology, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9317-4488","authenticated-orcid":false,"given":"Hui\u2010Qi","family":"Qu","sequence":"additional","affiliation":[{"name":"Center for Applied Genomics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumin","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital, Tianjin Clinical Research Center for Rheumatic and Immune Diseases  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital, Tianjin Clinical Research Center for Rheumatic and Immune Diseases  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital, Tianjin Clinical Research Center for Rheumatic and Immune Diseases  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital, Tianjin Clinical Research Center for Rheumatic and Immune Diseases  Tianjin China"},{"name":"Department of Cell Biology Department of Bioinformatics The Province and Ministry Cosponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), State Key Laboratory of Experimental Hematology, Tianjin Institute of Immunology, School of Basic Medical Sciences, Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital, Tianjin Clinical Research Center for Rheumatic and Immune Diseases  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa477"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-023-00297-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14840-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.7.437"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.09.012"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0201-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"issue":"3","key":"e_1_2_11_10_1","article-title":"ClusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu T","year":"2021","journal-title":"Innovation."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"issue":"3","key":"e_1_2_11_12_1","first-page":"477","article-title":"Modular transcriptional repertoire analyses identify a blood neutrophil signature as a candidate biomarker for lupus nephritis","volume":"56","author":"Jourde\u2010Chiche N","year":"2017","journal-title":"Rheumatology."},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts034"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0332-7"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220066"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-018-0558-x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.88623"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy147"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93831-3"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02914-4"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.01.003"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048687"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001924"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-007-9104-0"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.77"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.58"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106221"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-006595"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02767-19"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.3.217"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2007.11.014"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0684"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04238.x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.127428"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-018-0832-5"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016101100"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1195662"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1825"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp-2023-208945"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.036"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00622-3"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003475"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.07.021"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.033753"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(24)00095-X"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0602-9"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.915179"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213419"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11845-y"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.70027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T15:27:08Z","timestamp":1763134028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.70027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/joim.70027"],"URL":"https:\/\/doi.org\/10.1111\/joim.70027","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,6]]},"assertion":[{"value":"2025-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}