{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T15:31:55Z","timestamp":1763134315512,"version":"3.45.0"},"reference-count":76,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["K12TR004529"],"award-info":[{"award-number":["K12TR004529"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little is known about the initiation of alcohol use disorder (AUD) treatments among cancer survivors, despite the unique harms that unhealthy alcohol use may have on this population. We assessed patterns, timing, and predictors of AUD treatment among cancer survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used commercial claims data on US adult cancer survivors from 2011 to 2021 in this retrospective cohort study. We included individuals with a new AUD diagnosis and continuous insurance enrollment. We measured initiation and timing of Food and Drug Administration (FDA)\u2010approved (naltrexone, acamprosate, and disulfiram), non\u2010FDA\u2010approved (gabapentin, topiramate, and baclofen), and investigational (ondansetron and varenicline) medications for AUD (MAUDs), psychosocial therapies, and rehabilitation for AUD. We employed survival analysis to identify sociodemographic and clinical predictors of time to AUD treatment initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 6,682,292 cancer survivors, 44,081 individuals newly diagnosed with AUD met the inclusion criteria. Of these, 14.7% initiated FDA\u2010approved MAUDs (3.0%), psychosocial therapy (13.0%), or both (1.3%). The median time to initiate FDA\u2010approved MAUD or psychosocial therapy was 28 days. Overall, 6.3% and 10.4% of cancer survivors, respectively, initiated non\u2010FDA\u2010approved and investigational MAUDs. Age, use of antineoplastic agents, mental disorders, and comorbidity severity are potential determinants with varying effects on AUD treatment initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Less than 15% of cancer survivors initiated recommended MAUDs or psychosocial therapy in the year following their new AUD diagnoses, and those who did initiate treatment did so nearly a month after receiving AUD diagnoses. Interventions are warranted to enhance treatment initiation among cancer survivors with AUD to reduce alcohol\u2010related harms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.70033","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T03:25:01Z","timestamp":1761276301000},"page":"670-685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends, timing, and predictors of alcohol use disorder treatment among US adult cancer survivors"],"prefix":"10.1111","volume":"298","author":[{"given":"Jyun\u2010Heng","family":"Lai","sequence":"first","affiliation":[{"name":"Health Outcomes Division College of Pharmacy The University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4903-870X","authenticated-orcid":false,"given":"Anton L. V.","family":"Avance\u00f1a","sequence":"additional","affiliation":[{"name":"Health Outcomes Division College of Pharmacy The University of Texas at Austin  Austin Texas USA"},{"name":"Department of Internal Medicine Dell Medical School The University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh H. K.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Health Outcomes Division College of Pharmacy The University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corwin M.","family":"Zigler","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Public Health Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary M.","family":"Velasquez","sequence":"additional","affiliation":[{"name":"Health Behavior Research and Training Institute Steve Hicks School of Social Work The University of Texas at Austin  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"Frei","sequence":"additional","affiliation":[{"name":"Pharmacotherapy and Translational Sciences Division College of Pharmacy The University of Texas at Austin  Austin Texas USA"},{"name":"Pharmacotherapy Education and Research Center Joe R. and Teresa Lozano Long School of Medicine The University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Pignone","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine Duke University  Durham North Carolina USA"},{"name":"Duke Margolis Center for Health Policy Duke University  Durham North Carolina USA"},{"name":"Duke Cancer Institute Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-21-0934"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2004.07.030"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.7076"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-024-08940-2"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2018.01.003"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.7341"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2025.7007"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19761"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2024.2350056"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002572"},{"volume-title":"Disulfiram","year":"2025","author":"Stokes M","key":"e_1_2_13_12_1"},{"volume-title":"Naltrexone","year":"2025","author":"Singh D","key":"e_1_2_13_13_1"},{"key":"e_1_2_13_14_1","unstructured":"The U.S. Department of Veterans Affairs VA Pharmacy Benefits Management Academic Detailing Services.Alcohol use disorder (AUD) leading the charge in the treatment of AUD.The U.S. Department of Veterans Affairs VA Pharmacy Benefits Management Academic Detailing Services;2022.https:\/\/www.pbm.va.gov\/PBM\/AcademicDetailingService\/Documents\/508\/10\u20101530_AUD_ClinicianGuide_508Conformant.pdf. Accessed 11 Aug 2025."},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30866"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2022.109287"},{"key":"e_1_2_13_17_1","unstructured":"Substance Abuse and Mental Health Services Administration.2023 National Survey on Drug Use and Health (NSDUH) releases.2025.https:\/\/www.samhsa.gov\/data\/data\u2010we\u2010collect\/nsduh\u2010national\u2010survey\u2010drug\u2010use\u2010and\u2010health\/national\u2010releases\/2023. Accessed 11 Aug 2025."},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/M23-0641"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14837"},{"issue":"5","key":"e_1_2_13_20_1","article-title":"Prevalence and treatment for alcohol use disorders based on Kentucky Medicaid 2012\u20132019 datasets","volume":"10","author":"Hu H","year":"2022","journal-title":"J Alcohol Drug Depend."},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14609"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257025"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2022.108920"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-020-06073-w"},{"key":"e_1_2_13_25_1","unstructured":"National Committee for Quality Assurance.Initiation and engagement of substance use disorder treatment (IET).https:\/\/www.ncqa.org\/report\u2010cards\/health\u2010plans\/state\u2010of\u2010health\u2010care\u2010quality\u2010report\/initiation\u2010and\u2010engagement\u2010of\u2010substance\u2010use\u2010disorder\u2010treatment\u2010iet\/. Accessed 11 Aug 2025."},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP-24-01030"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-24-02679"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.josat.2024.209339"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.0528"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2015.03.008"},{"key":"e_1_2_13_31_1","unstructured":"UpToDate.2024.Alcohol use disorder: psychosocial management.https:\/\/www.uptodate.com\/contents\/alcohol\u2010use\u2010disorder\u2010psychosocial\u2010management. Accessed 11 Aug 2025."},{"key":"e_1_2_13_32_1","unstructured":"UpToDate.2025.Brief interventions for unhealthy alcohol and other substance use in adults.https:\/\/www.uptodate.com\/contents\/brief\u2010interventions\u2010for\u2010unhealthy\u2010alcohol\u2010and\u2010other\u2010substance\u2010use\u2010in\u2010adults. Accessed 11 Aug 2025."},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.16789"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.01.030"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.927703"},{"key":"e_1_2_13_36_1","unstructured":"PoseyKG.Household Income in States and Metropolitan Areas: 2022.U.S. Census Bureau;2023.https:\/\/www.census.gov\/content\/dam\/Census\/library\/publications\/2023\/acs\/acsbr\u2010017.pdf. Accessed 11 Aug 2025."},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e509"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.16156"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2021.1969658"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.14758"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.108964"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1296239"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0306066"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21719"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-020-00905-8"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06688-7"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.7657"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.20837"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agac057"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.2997"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.856938"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-017-4202-z"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21142"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.1155"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.3809"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21286"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21343"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz089"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-024-01602-6"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.14694\/EdBook_AM.2015.35.e583"},{"key":"e_1_2_13_61_1","unstructured":"Substance Abuse and Mental Health Services Administration.Screening brief intervention and referral to treatment (SBIRT).2024.https:\/\/www.samhsa.gov\/substance\u2010use\/treatment\/sbirt. Accessed 11 Aug 2025."},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.230715"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000014"},{"volume-title":"Ondansetron","year":"2024","author":"Griddine A","key":"e_1_2_13_64_1"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31389"},{"volume-title":"Incorporating alcohol pharmacotherapies into medical practice","year":"2009","author":"Center for Substance Abuse Treatment","key":"e_1_2_13_66_1"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.1750101"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.15118"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2022.04.002"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamahealthforum.2023.1018"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.3387"},{"key":"e_1_2_13_72_1","unstructured":"Specifications Manual for Joint Commission National Quality Measures (v2024A1).Measure set: substance use measures (SUB).2023.https:\/\/manual.jointcommission.org\/releases\/TJC2024A1\/MIF0221.html. Accessed 11 Aug 2025."},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2023.03.005"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.15287"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2019.80.572"},{"key":"e_1_2_13_76_1","unstructured":"American Psychological Association.How to bill for brief substance and alcohol abuse services.2024.https:\/\/www.apaservices.org\/practice\/reimbursement\/health\u2010codes\/substance\u2010alcohol\u2010abuse\u2010services. Accessed 11 Aug 2025."},{"key":"e_1_2_13_77_1","unstructured":"Substance Abuse and Mental Health Services Administration.Coding for screening and brief intervention reimbursement.2024.https:\/\/www.samhsa.gov\/substance\u2010use\/treatment\/sbirt\/coding. Accessed 11 Aug 2025."}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.70033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T15:27:13Z","timestamp":1763134033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.70033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":76,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/joim.70033"],"URL":"https:\/\/doi.org\/10.1111\/joim.70033","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"type":"print","value":"0954-6820"},{"type":"electronic","value":"1365-2796"}],"subject":[],"published":{"date-parts":[[2025,10,23]]},"assertion":[{"value":"2025-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}