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Participants were aged 55\u201375 years at follow\u2010up, occurring a median of 8.1 years after the baseline investigation. Standardized protocols replicated baseline imaging and functional assessments, including questionnaires, clinical assessments and extensive computer tomography imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Interim analyses of the first 5000 participants (50% women; median age 65.5 [61.8\u201369.1] years) indicated an expected age\u2010related increase in the prevalence and treatment of hypertension (from 22% to 37%) and diabetes (from 4% to 8%), together with a modest rise in central adiposity. Body mass index (median 26.6\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and the proportion of obesity (22%) remained largely stable, whereas current smoking decreased from 7.5% to 3.4%. The observed patterns were consistent in men and women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Here we present the rationale, design, methods and management of incidental findings in the SCAPIS re\u2010examination. By integrating serial imaging, functional testing and biomarker profiling, the re\u2010examination will furnish unprecedented insight into cardiopulmonary disease dynamics in an ageing population. These data will underpin personalized risk prediction and inform preventive strategies, while serving as a benchmark for future population\u2010based imaging cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.70068","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:29:57Z","timestamp":1768966197000},"page":"467-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Swedish CArdioPulmonary bioImage Study re\u2010examination: Rationale, design, methods, and management of incidental findings"],"prefix":"10.1111","volume":"299","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3418-1706","authenticated-orcid":false,"given":"Elin","family":"Good","sequence":"first","affiliation":[{"name":"Department of Health, Medicine &amp; Caring Sciences Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Department of Cardiology Link\u00f6ping University 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