{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:23:36Z","timestamp":1789687416125,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Current guidelines recommend at least 10 years of follow\u2010up for all pheochromocytoma and paraganglioma (PPGL) patients and lifelong monitoring for high\u2010risk individuals. Nonetheless, data identifying patients who may not require routine lifelong follow\u2010up are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Among 999 patients with PPGL, 703 who were non\u2010metastatic, non\u2010hereditary, and had undergone complete resection were included. Variables that significantly differed between the recurrence (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a050) and non\u2010recurrence groups over 10 years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a083) were identified, and cutoff values were determined using receiver\u2010operating characteristic curve analysis. These very low\u2010risk criteria were validated in an internal cohort and an external dataset from the National Institutes of Health.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The non\u2010recurrence group was older and had smaller pheochromocytomas (PCCs) than the recurrence group, with cutoffs of 37 years and 5.7\u00a0cm, respectively. The non\u2010recurrence group had a higher percentage of patients with pheochromocytoma of the adrenal gland scaled score (PASS) &lt;4 or grading system for adrenal pheochromocytoma and paraganglioma (GAPP) score &lt;3 (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.027). Age &gt;40 years (hazard ratio [HR] [95% confidence intervals] of 0.36 [0.17\u20130.76]), PCC size &lt;6\u00a0cm (HR\u00a0=\u00a00.43 [0.19\u20130.98]), and PASS &lt;4 or GAPP score &lt;3 (HR\u00a0=\u00a00.37 [0.16\u20130.89]) were associated with lower recurrence risk. None of the patients meeting all these criteria in the internal (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0114) and external (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a013) validation sets experienced recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests that routine lifelong follow\u2010up may be unnecessary for patients with sporadic PCC aged &gt;40 years, size &lt;6\u00a0cm, and PASS &lt;4 or GAPP score &lt;3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.70080","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:02:14Z","timestamp":1772989334000},"page":"615-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Who can safely discontinue lifelong follow\u2010up among patients with sporadic pheochromocytoma and paraganglioma?"],"prefix":"10.1111","volume":"299","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2204-2901","authenticated-orcid":false,"given":"Min Jeong","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Korea University Medical Center Guro Hospital  Seoul Republic of Korea"},{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5719-1539","authenticated-orcid":false,"given":"Seung Shin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Woong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of 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