{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:00:27Z","timestamp":1790744427096,"version":"4.1.0"},"reference-count":163,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary hyperparathyroidism (PHPT) is a common endocrine disease that typically presents in peri\u2010 and postmenopausal women. PHPT is due to a single parathyroid adenoma in most cases, which leads to stable hypercalcemia over years. Nowadays, the diagnosis is often coincidental, reached by chance in subjects without specific symptoms\u2014asymptomatic PHPT. However, the patients might have subtle disease\u2010related manifestations. Management standards have been reviewed through international workshops over more than three decades, leading to absolute and relative indications for parathyroidectomy (PTX), the only curative treatment. The alternative to PTX is observation without intervention in asymptomatic patients without organ manifestations and only mildly elevated calcium levels (mild PHPT). On the basis of recent literature, our aim is to challenge current recommendations for managing PHPT with focus on mild asymptomatic disease, integrating informed patient preferences. Considering the changing patient demography with increasing life expectancy, more sensitive visualization procedures, improved surgical techniques, and new data on PHPT\u2010related morbidity, we test some of the established indications for PTX, particularly age as an isolated criterion, and the validity of a circulating calcium \u201cthreshold\u201d for considering PTX. Additionally, bone mineral density (BMD) decreases for at least a decade with observation in contrast to PTX, where BMD normalizes after surgery and remains stable in the axial compartments for years. Therefore, skeletal\u2010related thresholds for PTX also deserve review. In conclusion, we suggest integrating more clinical outcomes and wider perspectives in decision\u2010making for the management of mild PHPT, taking patient preferences into consideration, and focusing on informed and shared decision\u2010making.<\/jats:p>","DOI":"10.1111\/joim.70089","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:54:58Z","timestamp":1775465698000},"page":"650-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Individualized management of primary hyperparathyroidism"],"prefix":"10.1111","volume":"299","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-4610","authenticated-orcid":false,"given":"Jens","family":"Bollerslev","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2558-9547","authenticated-orcid":false,"given":"Filomena","family":"Cetani","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Unit of Endocrinology, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5963-214X","authenticated-orcid":false,"given":"Neil","family":"Gittoes","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, Diabetes and Metabolism University of Birmingham and Queen Elizabeth Hospital  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0757-298X","authenticated-orcid":false,"given":"Lars","family":"Rolighed","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-77-4-557"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365517209081110"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90357-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0600"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.10.2398"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0589"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4677"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3441"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4763"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2020.02.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-017-0833-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0316"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4679"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14915"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/0118715303260423231122111705"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4682"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1763"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7162.848"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(98)70038-8"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvae109"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/M21-4416"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4199"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-1044"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad316"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-7-593"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1413"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021370"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4665"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.endonu.2013.04.014"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.12.003"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4022"},{"issue":"2","key":"e_1_2_10_33_1","article-title":"Increasing incidence of primary hyperparathyroidism in Denmark","volume":"60","author":"Abood A","year":"2013","journal-title":"Dan Med J."},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-025-02723-0"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230130"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad201"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbmrpl\/ziae065"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-020-01142-w"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2914"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/ije\/9936658"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050910"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-6-199703150-00003"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198001243020402"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2005000900013"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMED.S13147"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1062-2"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00239-0"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.14712\/23362936.2015.50"},{"issue":"2","key":"e_1_2_10_49_1","first-page":"86","article-title":"Is there a link between Hashimoto's thyroiditis and primary hyperparathyroidism? A study of serum parathormone and anti\u2010TPO antibodies in 2267 patients","volume":"16","author":"Ignjatovic VD","year":"2013","journal-title":"Hell J Nucl Med."},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4322-7"},{"issue":"8","key":"e_1_2_10_51_1","first-page":"651","article-title":"[A preliminary survey of primary hyperparathyroidism in middle\u2010aged and elderly Beijing Chinese]","volume":"46","author":"Yan ST","year":"2007","journal-title":"Zhonghua Nei Ke Za Zhi."},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2018.94.5.235"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.63.743.745"},{"issue":"2","key":"e_1_2_10_54_1","first-page":"113","article-title":"Hypercalcaemia in the Johannesburg Hospital. Differential diagnosis and physician awareness of primary hyperparathyroidism","volume":"72","author":"Diamond TH","year":"1987","journal-title":"S Afr Med J."},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2002.tb04756.x"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1415"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-023-02049-9"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1564352"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-023-07006-z"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae659"},{"key":"e_1_2_10_61_1","first-page":"1","article-title":"Normocalcemic primary hyperparathyroidism: a common disease in search of common standards","volume":"21","author":"Cusano NE","year":"2025","journal-title":"Expert Rev Endocrinol Metab."},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.18.2336"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-018-03624-3"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2932-y"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13010074"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107156"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2001.00868.x"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1258\/0004563011901037"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12188"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13661"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01517"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S86103"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3992"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-022-09709-1"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-19-0135"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad455"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-23-0492"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-017-1647-9"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2025.1346"},{"issue":"1","key":"e_1_2_10_81_1","first-page":"15","article-title":"Adenoma weight: the only predictive factor for multiple gland disease in primary hyperparathyroidism","volume":"50","author":"Lindner K","year":"2025","journal-title":"Minerva Endocrinol (Torino)."},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.08.054"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2020.05.049"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.08.007"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.09.018"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.8.777"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae577"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvaf222"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvaf204"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-009-0529-1"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5574"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000988"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2023.0389"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1442972"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4685"},{"key":"e_1_2_10_96_1","unstructured":"Office for National Statistics.National life tables \u2013 life expectancy in the UK: 2022 to 2024.Newport:Office for National Statistics;2024.https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/lifeexpectancies."},{"key":"e_1_2_10_97_1","unstructured":"Infoplease.US\u2014Life Expectancy by Age 1850\u20132011.Boston MA:Infoplease;2023.https:\/\/www.infoplease.com\/us\/health\u2010statistics\/life\u2010expectancy\u2010age\u20101850\u20102011."},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.07.032"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP10311.RA"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.06.062"},{"key":"e_1_2_10_101_1","volume-title":"Hyperparathyroidism (primary): diagnosis, assessment and initial management","author":"Excellence NIfHaC","year":"2019"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3177"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs5.77"},{"issue":"10","key":"e_1_2_10_104_1","article-title":"Minimally invasive parathyroidectomy guided by intraoperative parathyroid hormone monitoring (IOPTH) and preoperative imaging versus bilateral neck exploration for primary hyperparathyroidism in adults","volume":"10","author":"Ahmadieh H","year":"2020","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0363"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14217740"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.298"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvad098"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.03.044"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4689"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/128352"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2802"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302010000200004"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2018.09.010"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.09.012"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12291"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1744-x"},{"issue":"4","key":"e_1_2_10_118_1","first-page":"203","article-title":"Bias assessment of general chemistry analytes using commutable samples","volume":"35","author":"Koerbin G","year":"2014","journal-title":"Clin Biochem Rev."},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2003.06.001"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411701"},{"issue":"12","key":"e_1_2_10_121_1","first-page":"863","article-title":"Seventeen year follow\u2010up study of bone mass in patients with mild asymptomatic hyperparathyroidism some of whom were operated on","volume":"161","author":"Elvius M","year":"1995","journal-title":"Eur J Surg."},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.ijem_468_24"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445450"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1379"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvad081"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03162.x"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvae225"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018810382326"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-021-05822-9"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10482"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-022-06629-y"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0305"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2021.04.001"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1841"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab317"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae326"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2021.6437"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01932"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaf010"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-1232"},{"issue":"3","key":"e_1_2_10_141_1","article-title":"Bongaerts B. Parathyroidectomy for adults with primary hyperparathyroidism","volume":"3","author":"Pappachan JM","year":"2023","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0028"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0219"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.04.059"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-0322"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-019-01815-9"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.2310"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30063-2"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.1.113"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020890"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030908"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3978"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111639"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000240"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2025.101980"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03520.x"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad267"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2017.0112"},{"issue":"9","key":"e_1_2_10_159_1","first-page":"485","article-title":"Primary hyperparathyroidism: incidence and clinical and biochemical characteristics. A demographic study","volume":"160","author":"Mollerup CL","year":"1994","journal-title":"Eur J Surg."},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304-025-02086-4"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1836"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3461"},{"issue":"102","key":"e_1_2_10_163_1","first-page":"1","article-title":"The skeleton in primary hyperparathyroidism: a review focusing on bone remodeling, structure, mass, and fracture","volume":"2001","author":"Christiansen P","journal-title":"APMIS Suppl."},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934779"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.70089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joim.70089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.70089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:47:31Z","timestamp":1781516851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.70089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":163,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/joim.70089"],"URL":"https:\/\/doi.org\/10.1111\/joim.70089","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"assertion":[{"value":"2026-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}