{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:01:56Z","timestamp":1790229716050,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elevated blood pressure is common among hospitalized patients, but the effects of withholding chronic antihypertensive therapy during hospitalization remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the association between continuation versus discontinuation of chronic antihypertensive medications during hospitalization and short\u2010 and long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective propensity score\u2013matched cohort study included adults (\u226518 years) with chronic hypertension hospitalized in eight Clalit Health Services hospitals in Israel from January 2014 to May 2024. Eligible patients had received at least one antihypertensive medication continuously for 6 months before admission. Discontinuation was defined as omission of \u22651 chronic medication during hospitalization. Outcomes included in\u2010hospital and 90\u2010day acute kidney injury (AKI), myocardial injury, stroke, and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 1:1 propensity matching, 82,230 patients were analyzed (50,070 internal medicine; 32,160 surgical). In internal medicine departments, discontinuation was associated with higher risk of in\u2010hospital AKI (OR, 1.23; 95% CI, 1.16\u20131.30), 90\u2010day AKI (OR, 1.19; 95% CI, 1.14\u20131.24), in\u2010hospital mortality (OR, 2.69; 95% CI, 2.47\u20132.94), and 90\u2010day mortality (OR, 1.81; 95% CI, 1.72\u20131.90). In surgical departments, discontinuation was linked to in\u2010hospital myocardial injury (OR, 1.26; 95% CI, 1.10\u20131.44) but not AKI. Results were consistent across subgroups, including infection\u2010related admissions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Discontinuing chronic antihypertensive therapy during hospitalization was associated with increased risks of AKI and mortality. These findings suggest that withholding antihypertensive therapy is unlikely to confer benefit and may be harmful.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.70093","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:10:44Z","timestamp":1775211044000},"page":"284-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stopping or continuing chronic antihypertensive therapy during hospitalization"],"prefix":"10.1111","volume":"300","author":[{"given":"Ziv","family":"Ribak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine F Soroka University Medical Center and Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3631-2099","authenticated-orcid":false,"given":"Jacob David","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H Soroka University Medical Center and Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitzan","family":"Burrack","sequence":"additional","affiliation":[{"name":"Clinical Research Center Soroka University Medical Center and Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Novack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H Soroka University Medical Center and Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer Sheva Israel"},{"name":"Clinical Research Center Soroka University Medical Center and Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Abuhasira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine H Soroka University Medical Center and Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer Sheva Israel"},{"name":"Clinical Research Center Soroka University Medical Center and Faculty of Health Sciences, Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization:Hypertension https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/hypertension(2025). 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