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Clinical disease activity index (CDAI) flares (\u22654.5 increase in CDAI score) were assessed longitudinally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Up to 48 weeks, flare occurred at least once in 43% of oral GC, 24% of injection GC and 28% of bDMARD patients. Over\u2010time relative risk (RR) was higher with oral GC bridging (adjusted RR, 1.54; 95% CI, 1.16\u20132.03) but similar with injection GC bridging (adjusted RR 0.93; 95% CI, 0.54\u20131.55) versus bDMARD. Flare rates were numerically higher in the oral GC versus bDMARD group at all time points (12, 24, 32, 40 and 48 weeks), with a significant difference at w.40, the visit after protocol\u2010defined GC discontinuation; at this visit 27% of patients who discontinued GC experienced flare; 29% among those in remission; 33% remained on low\u2010dose prednisolone at 48\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Discontinuation of oral GC bridging therapy on background MTX is associated with increased flare risk, even among patients in remission. Flare rates with IA GC bridging plus triple therapy did not differ from the bDMARD group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>EudraCT 2011\u2010004720\u201035; ClinicalTrials.gov NCT01491815.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.70094","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:06:14Z","timestamp":1775541974000},"page":"741-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Flare risk after oral glucocorticoid bridging with methotrexate or intra\u2010articular bridging with triple therapy in early rheumatoid arthritis"],"prefix":"10.1111","volume":"299","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5037-5546","authenticated-orcid":false,"given":"Kristina","family":"Lend","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Medicine Center for Molecular Medicine (CMM) Karolinska Institute  Stockholm Sweden"},{"name":"Department of Rheumatology and Clinical Immunology Amsterdam University Medical Centers  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos W. 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