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However, a major change in this situation is currently taking place. Over the past few years, several new biological therapeutics have been approved for the treatment of SLE (belimumab and anifrolumab) or specifically for its renal organ manifestation (obinutuzumab), along with one new small molecular treatment for the latter (voclosporin). Several additional biologicals (litifilimab and dapirolizumab) and small molecules (deucravacitinib, upadacitinib, and cerenimod) are in late\u2010stage clinical development. Moreover, multiple case series and case reports have been published in the past years demonstrating excellent individual results following treatments aimed at fully depleting B lymphocytes using chimeric antigen receptor bearing T cells (CAR\u2010T cells) or bi\u2010specific T\u2010cell engagers. These reports have raised hopes that not only solid disease control, but also a more profound state of immunological reset\u2014deep remission\u2014can be attained in at least some patients. In this narrative review, these developments will be described, emphasizing both the promises and the challenges they bring about, leading into some predictions of where they may lead to. A reasonable expectation is that in the coming 1\u20132 years, several additional biologicals and small\u2010molecular agents will be approved for the treatment of lupus. The most important conclusion is that the future for our patients with lupus looks brighter than ever before.<\/jats:p>","DOI":"10.1111\/joim.70146","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:38:02Z","timestamp":1785926282000},"page":"461-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Advances in the treatment of systemic lupus erythematosus: Biologicals, small\u2010molecular agents, and cell\u2010depleting therapies coming to the clinic"],"prefix":"10.1111","volume":"300","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6438-8663","authenticated-orcid":false,"given":"Ronald","family":"van Vollenhoven","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Amsterdam University Medical Center  Amsterdam the Netherlands"},{"name":"Department of Rheumatology and Immunology Semmelweis University  Budapest 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