{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:44:07Z","timestamp":1792125847155,"version":"4.4.0"},"reference-count":159,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prader\u2013Willi syndrome (PWS) is a rare, neurodevelopmental, multisystemic syndrome caused by lack of expression of paternal genes on chromosome 15q11.2\u201313. PWS is characterized by muscular hypotonia, abnormal body composition, hormone deficiencies, cognitive dysfunction and behavioural issues, including hyperphagia, increasing the risk of severe obesity. A single causative gene for hyperphagia has not been identified, and regulation of hunger and satiety is complex and multifactorial, making it difficult to identify a specific neuropeptide or hormone as the most important. Cornerstone treatments are a strict, controlled diet and regular physical activity. Several clinical trials with different pharmacological agents have been performed attempting to reduce or treat hyperphagia and obesity. However, many drug programmes have been discontinued due to adverse events or not reaching endpoints. In this review, we have focused on phenomenology and management of hyperphagia, treatment with oxytocin (OT), glucagon\u2010like\u2010peptide\u20101 receptor agonists (GLP\u20101RA) and diazoxide choline. We conclude that controlled food access is crucial; managing expectations about food mitigates food\u2010related behaviour; OT treatment of infants with PWS results in less severe hyperphagia at ages 3 and 4 years old; and that the effects of GLP\u20101RA on body weight seem modest. Studies of diazoxide choline extended\u2010release (DCCR), the first approved treatment of hyperphagia in PWS, have shown promising results, particularly in managing severe hyperphagia, reducing fat mass and improving behavioural issues. Thus, although progress is being made in targeted pharmacological therapies to control hyperphagia, controlled food access remains crucial to prevent obesity but is not sufficient for management of food\n                    <jats:italic>and<\/jats:italic>\n                    behaviour.\n                  <\/jats:p>","DOI":"10.1111\/joim.70173","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:50:19Z","timestamp":1792122619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of hyperphagia and obesity in Prader\u2013Willi syndrome"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3980-1927","authenticated-orcid":false,"given":"Charlotte","family":"H\u00f6ybye","sequence":"first","affiliation":[{"name":"Department of Endocrinology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4510-0545","authenticated-orcid":false,"given":"Janice","family":"Foster","sequence":"additional","affiliation":[{"name":"The Pittsburgh Partnership specialists in PWS  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8179-7071","authenticated-orcid":false,"given":"Anthony P.","family":"Goldstone","sequence":"additional","affiliation":[{"name":"PsychoNeuroEndocrinology Research Group Division of Psychiatry Department of Brain Sciences Faculty of Medicine Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4485-1966","authenticated-orcid":false,"given":"Linda","family":"Gourash","sequence":"additional","affiliation":[{"name":"The Pittsburgh Partnership specialists in PWS  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Endocrinology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0363-7862","authenticated-orcid":false,"given":"Maith\u00e9","family":"Tauber","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, H\u00f4pital des Enfants CHU Toulouse  Toulouse France"},{"name":"INFINITY, INSERM U1291, Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010017\u20100673\u20106"},{"key":"e_1_2_7_3_1","volume-title":"GeneReviews\u00ae","author":"Driscoll DJ","year":"1993"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12994"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(21)00002\u20104"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102788.2000.00250.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010002\u20101132\u20104"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11020204"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194655"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20646"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47030192"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac229"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002\u2010020871"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010020\u201001440\u20106"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12992"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.9.7814"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.117.016253"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13953"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112528"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/AHMT.S214893"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S141352"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2021.104379"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14041307"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2022.01127"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032150"},{"key":"e_1_2_7_26_1","first-page":"235","article-title":"Prader\u2013Willi syndrome: the more we know, the less we know","volume":"121","author":"Whitman BY","year":"2024","journal-title":"Missouri Med."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33951"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.32641\/andespediatr.v92i3.2400"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plabm.2024.e00405"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.663"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36810"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000534560"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12728"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac105"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/23333936241242929"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/46.2.277"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.118"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.204"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102788.2009.01169.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163555"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787\u2010024\u201002631\u20103"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23660"},{"key":"e_1_2_7_43_1","unstructured":"ForsterJ FangmanE DuisJ ManzardoA.Developmental characterization of phenotypic behaviors.Presented at Clinical and scientific meeting of the IPWSO conference Phoenix AZ USA;2025."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.08.067"},{"key":"e_1_2_7_45_1","unstructured":"ForsterJL GourashLM RoyleM.A preliminary description of PWS behaviors across the lifespan: stability and change.Presented at: 30th annual PWSA (USA) national conference Milwaukee WI USA;2008."},{"key":"e_1_2_7_46_1","volume-title":"Food, behavior and beyond: practical management for the child and adult with PWS [DVD]","author":"Gourash LM","year":"2005"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cdn\/nzac120"},{"key":"e_1_2_7_48_1","unstructured":"BalkoK.Red yellow green system for weight management.Toronto Ontario Canada:Ontario Prader\u2013Willi Syndrome Association;2005."},{"key":"e_1_2_7_49_1","unstructured":"BerallG GourashLM ForsterJL.Lessons from Prader\u2013Willi syndrome: integrating weight and behavior management.Presented at: 52nd annual meeting of the American Academy of Child and Adolescent Psychiatry Toronto Canada;2005."},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.80.2.7852513"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.20.3101"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq424"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.11.010"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaf008"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489263"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb45060313"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20106\u201047"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36653"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13169"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38160"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14387"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.11.006"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98333"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad015"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2023.102711"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.120.019398"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1831"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-024-02542-4"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20\u201015\u201005813.2000"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1183525"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-025-03560-3"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-026-04214-8"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00213-0"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.3224"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.1831"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02026-4"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00008-0"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.23619"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2208601"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14255"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23673"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12589"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16205"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2015.03.005"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22653"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.03.009"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obpill.2023.100080"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2024.100333"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.619"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14551"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-025-01859-6"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1431292"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03280.x"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2010.12.009"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0038"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.ej12-0074"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12131"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2019-0389"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2020.25.1.52"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194540"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14583"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.35102"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac549"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530322666220509225637"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1533209"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.endien.2023.12.001"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1528457"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2026.1881392"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(25)00225-6"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(25)00226-8"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002563\u20101111"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2416394"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2026.02.002"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1159\/000105447"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2010.140"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31805b82b5"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096-8628(19971231)73:4<437::aid-ajmg12>3.0.co;2-s"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.12659\/ajcr.903608"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.178"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.91.2.398"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38015"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/68.3.525"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.3.R910"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801627"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802418851"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.162"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13120"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-018-3249-1"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-023-02549-5"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23941"},{"key":"e_1_2_7_132_1","first-page":"S344","article-title":"Assessing gastric emptying before and after introduction of GLP\u20101 agonists for glycaemic and body weight control in Prader\u2010Willi syndrome","volume":"21","author":"Ali SN","year":"2013","journal-title":"Obesity (Silver Spring)."},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34171"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12140"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-14-63"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina61111987"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2025.1133"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2025.1794"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2025.09.017"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11040450"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2018.02.018"},{"key":"e_1_2_7_142_1","unstructured":"SalehiP CharltonW CowenNM.Pharmacokinetics of diazoxide choline controlled\u2010release tablets a once\u2010a\u2010day treatment being evaluated in patients with Prader\u2010Willi syndrome.Presented at: 57th annual meeting of the European Society for Pediatric Endocrinology Athens Greece;2018."},{"key":"e_1_2_7_143_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad014"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23928"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-024-09536-x"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaf661"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010021\u201001470\u20109"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010016\u20100440\u20100"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010015\u20100614\u2010x"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190849"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707133"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.10.004"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026619666190708164841"},{"issue":"1","key":"e_1_2_7_154_1","doi-asserted-by":"crossref","DOI":"10.12771\/emj.2023.e32","article-title":"Management of hyperphagia and obesity in Prader\u2013Willi syndrome","volume":"46","author":"Hwang J","year":"2023","journal-title":"Ewha Med J."},{"key":"e_1_2_7_155_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.1.02165"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13021"},{"key":"e_1_2_7_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2024.e00339"},{"key":"e_1_2_7_158_1","doi-asserted-by":"publisher","DOI":"10.17476\/jmbs.2025.14.2.85"},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000304458.30294.31"},{"key":"e_1_2_7_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.endien.2022.11.021"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.70173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joim.70173","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.70173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:50:21Z","timestamp":1792122621000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.70173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":159,"alternative-id":["10.1111\/joim.70173"],"URL":"https:\/\/doi.org\/10.1111\/joim.70173","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"assertion":[{"value":"2026-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"joim.70173"}}